Peer Review Report For: Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 1; peer review: 2 approved]
Rattachement africain : au, gb, us, vn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: The w Mel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown in laboratory studies to reduce transmission of a range of viruses including dengue, Zika, chikungunya, yellow fever, and Mayaro viruses that cause human disease. Here we report the entomological and epidemiological outcomes of staged deployment of Wolbachia across nearly all significant dengue transmission risk areas in Australia. Methods: The w Mel strain of Wolbachia was backcrossed into the local Aedes aegypti genotype (Cairns and Townsville backgrounds) and mosquitoes were released in the field by staff or via community assisted methods. Mosquito monitoring was undertaken and mosquitoes were screened for the presence of Wolbachia . Dengue case notifications were used to track dengue incidence in each location before and after releases. Results: Empirical analyses of the Wolbachia mosquito releases, including data on the density, frequency and duration of Wolbachia mosquito releases, indicate that Wolbachia can be readily established in local mosquito populations, using a variety of deployment options and over short release durations (mean release period 11 weeks, range 2-22 weeks). Importantly, Wolbachia frequencies have remained stable in mosquito populations since releases for up to 8 years. Analysis of dengue case notifications data demonstrates near-elimination of local dengue transmission for the past five years in locations where Wolbachia has been established. The regression model estimate of Wolbachia intervention effect from interrupted time series analyses of case notifications data prior to and after releases, indicated a 96% reduction in dengue incidence in Wolbachia treated populations (95% confidence interval: 84 – 99%). Conclusion: Deployment of the w Mel strain of Wolbachia into local Ae. aegypti populations across the Australian regional cities of Cairns and most smaller regional communities with a past history of dengue has resulted in the reduction of local dengue transmission across all deployment areas.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Peer Review Report For: Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia [version 1; peer review: 2 approved]
- Date Crossref
- 18/10/2019
- Éditeur
- F1000 Research Ltd
- Type
- peer-review
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Monash University Institute of Vector-Borne Disease pays non établi dans la noticeUniversité ou école supérieure
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Government of Victoria pays non établi dans la noticeOrganisme public
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Department of Jobs pays non établi dans la noticeOrganisme public
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Queensland Health pays non établi dans la noticeOrganisme public
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James Cook University pays non établi dans la noticeUniversité ou école supérieure
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The University of Melbourne pays non établi dans la noticeUniversité ou école supérieure
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London School of Hygiene & Tropical Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of California pays non établi dans la noticeUniversité ou école supérieure
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Oxford University Clinical Research Unit pays non établi dans la noticeStructure de recherche
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Biosecurity and Agricultural Services pays non établi dans la noticeInstitution
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Metro South Public Health Unit pays non établi dans la noticeInstitution
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College of Public Health pays non établi dans la noticeUniversité ou école supérieure
Institute of Vector-Borne Disease — Monash University, Government of Victoria et Department of Jobs, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.