Tumor microenvironment-responsive cerium oxide nanozyme coated ZIF-8 nanoplatform with ICG encapsulation for precise breast cancer surgery and efficacious synergistic suppression

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Strategically designing and utilizing nanomaterials with enhanced therapeutic capabilities offers a solution to mitigate the financial burden of treatment and address the subpar efficacy of existing breast cancer treatments. In this study, we introduce a one-step synthesis of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, where indocyanine green (ICG) is encapsulated and CeO 2 nanozymes along with polyethylene glycol (PEG) are anchored onto the surface, forming ZIF-Ce&ICGP. This nanosystem presents precise tumor accumulation and responsiveness to the acidic tumor microenvironment, facilitating the intracellular release of ICG, Zn 2+ , and CeO 2 nanoparticles from the nanocarriers. In particular, the engineered ZIF-Ce&ICGP achieves accurate delineation of tumor margins, and tumors can be completely removed under fluorescence imaging guidance. Notably, under laser irradiation, the generation of a photothermally amplified ROS storm via bimetallic catalysis effectively inhibited tumor cells both in vitro and in vivo . Furthermore, ZIF-Ce&ICGP demonstrated extended blood circulation times and excellent biocompatibility. Overall, this research presents a promising nanoplatform for oncological therapy, expanding the utility of ZIF-8 in the realm of combinatorial cancer treatments.

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