Genetic control of malaria transmission: a salivary gland-centric perspective

Le résumé fourni par la source

Mosquitoes are the deadliest organisms on Earth, as they transmit a wide range of medically important diseases, posing a major public health threat worldwide. Controlling vector-borne diseases presents numerous challenges, and the alarming rise in their incidence underscores the urgent need for innovative strategies, with genetic control offering a promising approach. Genetic engineering of mosquitoes requires a profound understanding of mosquito physiology and molecular aspects of host–pathogen interactions. Over the years, several stages of the Plasmodium parasite development within the mosquito have been extensively studied, with many molecular mechanisms successfully elucidated. However, important features of the parasite journey remain unclear, particularly the sporozoite’s ability to recognize and invade the salivary glands. This process involves a complex interplay of proteins and other molecules, yet much remains to be discovered about the precise mechanisms at play. Advancing our knowledge of this critical step will be instrumental in designing more effective transgenes for genetic control strategies, particularly those aimed at mosquito population replacement. • Seven salivary gland promoter sequences have been characterized in mosquitoes and are available for driving transgene expression. • These promoter sequences can drive expression across all lobes of the mosquito salivary gland, each with distinct features. • Most effector molecules targeting sporozoites act on the non-infective stage, prior to salivary gland invasion. • Developing new transgenes that target infective sporozoites within the salivary glands could help eliminate residual parasites and ultimately block transmission.

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