Emerging human cases of sporotrichosis associated with feline outbreaks of Sporothrix brasiliensis in the Argentine Triple Frontier Region
Rattachement africain : ar, pt, us, co. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
• Outbreak of zoonotic sporotrichosis caused by Sporothrix brasiliensis in Iguazu city. • Isolates from human and feline cases belonged to a monophyletic S. brasiliensis clade. • Feline cases preceded human cases by approximately 7 months. • Spatial analysis identified high-density clusters of cases in the urban core. • These findings highlight the critical need for a One Health approach. Sporotrichosis, caused by Sporothrix brasiliensis , is an emerging zoonotic mycosis that poses increasing risks in Latin America, particularly in underserved urban areas, with intensified human–animal–environmental interactions. Recently, Puerto Iguazú, Misiones, Argentina, a biodiversity hotspot in the Triple Frontier (Argentina, Brazil, and Paraguay), reported outbreaks suggestive of sustained feline sporotrichosis transmission. This prospective, observational study used passive surveillance, set in a One Health framework, to characterize the epidemiological features of feline sporotrichosis and associated zoonotic transmission to humans in Puerto Iguazú over a 21 month period, between August 2023 and April 2025. Domestic cats [cat(s); Felis catus ], with suspected or confirmed sporotrichosis, and humans, with compatible cutaneous lesions and known contact with sick cats, were included. Laboratory confirmation involved culture, microscopy, and sequencing (ITS and CAL genes), with temporal and spatial analyses also performed. A combined total of 35 (44.9%) of 78 cats from 57 households were classified as confirmed or probable sporotrichosis, with S. brasiliensis isolated from 26 (74.3%) of these cases. Three asymptomatic cats tested positive for sporotrichosis via nasal swabs. Four human cases were identified, all with prior exposure to infected cats. Phylogenetic analysis confirmed all isolates clustered within the S. brasiliensis clade. A seven-month gap separated the first feline and human cases, with temporal analyses showing a progressive increase in feline cases, often preceding human infections in the same household. Spatial mapping identified a primary cluster in the northwestern urban core near the Iguazú River. This study documents the largest zoonotic sporotrichosis outbreak reported in Argentina to date and underscores the urgent need for integrated One Health surveillance, early detection, and inclusion of asymptomatic animals in control strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Emerging human cases of sporotrichosis associated with feline outbreaks of Sporothrix brasiliensis in the Argentine Triple Frontier Region
- Date Crossref
- 01/01/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National University of Misiones pays non établi dans la noticeUniversité ou école supérieure
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Instituto Nacional de Investigação Agrária e Veterinária pays non établi dans la noticeStructure de recherche
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Administración Nacional de Laboratorios e Institutos de Salud pays non établi dans la noticeOrganisme public
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Instituto Nacional de Medicina Tropical pays non établi dans la noticeUniversité ou école supérieure
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Saint Louis Zoo pays non établi dans la noticeInstitution
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Military University Nueva Granada pays non établi dans la noticeUniversité ou école supérieure
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Instituto Misionero de Biodiversidad pays non établi dans la noticeStructure de recherche
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Instituto de Investigación en Veterinaria pays non établi dans la noticeStructure de recherche
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Instituto Nacional de Enfermedades Infecciosas ANLIS - "Carlos G. Malbrán" pays non établi dans la noticeStructure de recherche
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Hospital SAMIC pays non établi dans la noticeÉtablissement de santé
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Dirección Municipal de Zoonosis pays non établi dans la noticeInstitution
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Clínica veterinaria pays non établi dans la noticeÉtablissement de santé
National University of Misiones, Instituto Nacional de Investigação Agrária e Veterinária et Administración Nacional de Laboratorios e Institutos de Salud, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.