Thermal degradation kinetics and behavior of MPN from Ginkgo biloba

Le résumé fourni par la source

Herein, we investigated the thermal degradation kinetics and behavior of 4′-O-methylpyridoxine (MPN) a toxic component in Ginkgo biloba seeds (GBSs), to advance its thermal detoxification strategies. Using a multi-analytical approach—including thermogravimetric analysis (TGA), coupled thermogravimetry–Fourier transform infrared spectroscopy–mass spectrometry (TG–FTIR–MS), pyrolysis–gas chromatography/mass spectrometry (Py-GC/MS), and HPLC-IT-TOF-MS, we identified methanol as the key volatile product and revealed that degradation initiates with cleavage of the 4′-methoxy C–O bond within 303–523 K. Kinetic analysis quantified the mean activation energy at 105–106 kJ/mol, indicating an energy-intensive process that follows a random nucleation and growth model, accompanied by the formation of non-volatile dimers. Toxicity assessment shows that the acute toxicity of degradation products is reduced. These findings offer a scientific basis for optimizing thermal processing parameters to enhance the safety of GBSs in food and medicinal applications.

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