Frailty and the brain: A narrative review of functional and pathological correlates
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Le résumé fourni par la source
Frailty influences the risk, phenotypic expression, and course of highly prevalent neurological conditions. However, the structural, functional, and pathological changes in the brain associated with frailty remain insufficiently explored. This narrative review examines existing evidence on the functional and pathological brain correlates of frailty in both healthy adults and patients with neurological conditions, encompassing findings from neuropathology, fluid biomarkers, neuroimaging, and neurophysiology. Autopsy studies suggest that individuals experiencing frailty may exhibit decreased resistance and resilience to neuropathological changes, along with heightened cognitive vulnerability, even in the presence of low levels of pathology. The accumulation of brain pathology may, in turn, play a role in accelerating frailty progression. Numerous MRI-based studies have shown that frailty is associated with vascular brain damage, mostly consisting of increased white matter hyperintensity volumes, and with reduced gray matter volumes. Additionally, variations in cerebrospinal fluid and plasma biomarkers of Alzheimer’s disease pathology have been documented. Furthermore, frailty-related changes in EEG/MEG signals and brain plasticity suggest potential widespread neural dysfunction. Future research is needed to elucidate the pathophysiological mechanisms underlying the neurological correlates of frailty. This exploration should encompass key aspects of aging, such as inflammation, mitochondrial dysfunction, and impaired proteostasis. Gaining a deeper understanding of the relationship between frailty and brain function and pathology could pave the way for discovering novel biomarkers and intervention targets, ultimately impacting the prevention and management of age-related neurological conditions. • Frailty is associated with vascular brain damage and neuronal loss. • Frailty has been linked to AD pathological changes in CSF and blood biomarkers. • Higher frailty degrees predict incident dementia independent of neuropathology. • The mechanisms linking frailty and brain function and pathology need exploration. • Exploring neurological correlates of frailty may reveal new treatment targets.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Frailty and the brain: A narrative review of functional and pathological correlates
- Date Crossref
- 01/01/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Institute of Health National Centre for Disease Prevention and Health Promotion pays non établi dans la noticeOrganisme public
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University of Modena and Reggio Emilia Department of Biomedical pays non établi dans la noticeUniversité ou école supérieure
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Azienda Unita' Sanitaria Locale Di Modena pays non établi dans la noticeOrganisme public
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Stockholm University Aging Research Center pays non établi dans la noticeUniversité ou école supérieure
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Karolinska Institutet pays non établi dans la noticeUniversité ou école supérieure
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Pasqual Maragall Foundation pays non établi dans la noticeOrganisation à but non lucratif
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University of Milano-Bicocca pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliero-Universitaria di Modena pays non établi dans la noticeÉtablissement de santé
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National Centre for Disease Prevention and Control pays non établi dans la noticeOrganisme public
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Sapienza University of Rome Department of Human Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine and Surgery Italy pays non établi dans la noticeUniversité ou école supérieure
National Centre for Disease Prevention and Health Promotion — National Institute of Health, Department of Biomedical — University of Modena and Reggio Emilia et Azienda Unita' Sanitaria Locale Di Modena, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.