EFFECT OF PNEUMOCOCCAL CONJUGATE VACCINE ON THE LENGTH OF HOSPITALIZATION IN CHILDREN UNDER FIVE WITH PNEUMONIA IN BURKINA FASO

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ABSTRACT Background Pneumococcus is a leading cause of childhood morbidity and mortality worldwide. We assessed the impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on the hospitalization length among children under five years hospitalized for pneumonia in Burkina Faso. Methods We conducted a secondary analysis of data collected from hospitalized pneumonia cases participating in a diagnostic validation study between December 2015 and January 2017. A Cox proportional hazards model was used to assess the association between vaccination status and time to discharge. Results A total of 280 children were included, of whom 187 (66.8%) had received three PCV13 doses. The mean hospitalization duration was 7.99 days (95% CI 7.17–8.81) for those fully vaccinated vs. 10.44 days (95% CI 9.07–11.80) among children with <3 doses. Full vaccination was associated with a significantly higher recovery rate (aHR: 1.45; 95% CI: 1.11–2.08, p = 0.01). Conclusion PCV13 significantly reduces hospitalization length due to pneumonia among children under five in Burkina Faso.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.