Is Appendicular Lean Soft Tissue Mass a Clinically Valid Diagnostic Marker for Sarcopenia?
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Le résumé fourni par la source
AIM: Geriatric experts have long debated the inclusion of appendicular lean soft tissue mass (ALSTM) in the diagnostic criteria for sarcopenia. This study examined whether a diagnostic model for sarcopenia that excludes appendicular lean soft tissue mass (ALSTM) is equivalent to one that includes ALSTM in discriminating health-related outcomes. METHODS: Community-dwelling older adults from the Itabashi Longitudinal Study on Aging in Tokyo, Japan, were included. Based on the AWGS2019 criteria, we developed two diagnostic models: Model 1, including low handgrip strength/gait speed and low ALSTM assessed by bioelectrical impedance analysis, and Model 2, excluding low ALSTM. Health-related outcomes were self-reported falls and hospitalization in the past year. Differences in area under the receiver operating characteristic curve (AUC) and 95% confidence intervals (CI) between the two models were estimated using 1000 bootstrap samples. RESULTS: In total, 2432 participants (median age: 76 years; 53.2% men) without missing data were analyzed. Falls and hospitalization were reported by 17.8% and 15.3% of participants, respectively. The AUCs [95% CIs] of Models 1 and 2 were 0.61 [0.59, 0.64] and 0.61 [0.58, 0.64] for falls and 0.65 [0.62, 0.68] and 0.64 [0.61, 0.67] for hospitalization, respectively. The differences (Model 2-Model 1) in AUCs [95% CI] between the two models were -0.004 [-0.015, 0.006] for falls and -0.004 [-0.014, 0.004] for hospitalization, with the CIs within the pre-specified equivalence margin (±0.05). CONCLUSIONS: Diagnostic models excluding ALSTM demonstrated equivalent discrimination ability to those including ALSTM, raising questions about the necessity of ALSTM assessment for sarcopenia diagnosis.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Is Appendicular Lean Soft Tissue Mass a Clinically Valid Diagnostic Marker for Sarcopenia?
- Date Crossref
- 18/11/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tokyo Metropolitan Institute of Gerontology pays non établi dans la noticeStructure de recherche
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National Center for Geriatrics and Gerontology pays non établi dans la noticeÉtablissement de santé
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Hokkaido University Department of Oral Health Science pays non établi dans la noticeUniversité ou école supérieure
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Department of Frailty Research Center for Gerontology and Social Science pays non établi dans la noticeStructure de recherche
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Tokyo Metropolitan Institute for Geriatrics and Gerontology Itabashi Tokyo Japan Research Team for Promoting Independence and Mental Health pays non établi dans la noticeStructure de recherche
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Research Institute Department of Frailty Research pays non établi dans la noticeStructure de recherche
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Graduate School of Dental Medicine Department of Oral Health Science pays non établi dans la noticeUniversité ou école supérieure
Tokyo Metropolitan Institute of Gerontology, National Center for Geriatrics and Gerontology et Department of Oral Health Science — Hokkaido University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.