A Rare Shift From Hypothyroidism to Hyperthyroidism: The Unusual Thyroid Journey After Hematopoietic Stem Cell Transplant in 2 Pediatric Cases.

Résumé fourni par la source

Thyroid dysfunction is a well-recognized complication following hematopoietic stem cell transplant, com-monly manifested as nonimmune hypothyroidism secondary to chemotherapy and total body irradiation. Autoimmune thyroid diseases, including Graves disease and Hashimoto thyroiditis, are uncommon. Sequential development of hypothyroidism and hyperthyroidism after hematopoietic stem cell transplant is extremely rare and has only been reported in isolated case reports. We present 2 pediatric cases of this transition and explore the possible pathophysiological mechanisms and implications for long-term endocrine surveillance in hematopoietic stem cell transplant survivors.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.