Infection responsive bio-nanoparticles as "molecular sprayer " for infection-repair integration via direct sterilization and macrophage polarization regulation
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Le résumé fourni par la source
Bone tissue destruction and related complications caused by bacterial infection remain a major challenge in clinical treatment. Existing therapies generally fail to balance the process of infection control and tissue repair simultaneously. In this study, infection microenvironmental-responsive multifunctional "molecular sprayer" nanocomposites (NP@D/AMP) were developed by loading 2-(1, 8-naphthidine -2-yl) phenol (2-NP) onto dendritic mesoporous silica nanoparticles (DMSNs), then encapsulating GW18 with polydopamine for sealing, which achieved the integrated functions of antibacteria, immune regulation and promoting bone formation. NP@D/AMP can sequentially release GW18 and 2-NP under the acidic microenvironment at the infectious site, where GW18 shows strong antibacterial and biofilm inhibition ability against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) through electrostatic interaction as well as 2-NP activates macrophages into M1 macrophages to synergistically enhance the antibacterial immune response and improve the inflammatory microenvironment. Notably, NP@D/AMP can also significantly promote osteogenic differentiation in vitro and accelerate bone repair in vivo . In brief, nanocomposite NP@D/AMP has demonstrated sustained and surprising antibacterial activity with macrophage regulation and bone formation efficacy in the treatment model of bone infection. Our study provides an innovative "antibacteria - immune balance - tissue repair" synergistic integrated therapy strategy for infectious bone defects. • NP@D/AMP is prepared by filling 2-NP into DMSN mesopores and then being sealed by antimicrobial peptide GW18 and polydopamine outside. • NP@D/AMP has comprehensive functions of eliminating E. coli and S. aureus , inhibiting and eradicating biofilms, activating the M1 polarization of macrophages and promoting the osteogenic differentiation in vitro. • NP@D/AMP as "molecular sprayer" has achieved "bacteria elimination - immune balance - tissue repair" synergistic integrated therapy in infectious bone defects. • NP@D/AMP has excellent biocompatibility.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Infection responsive bio-nanoparticles as "molecular sprayer " for infection-repair integration via direct sterilization and macrophage polarization regulation
- Date Crossref
- 01/03/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kunming University of Science and Technology Department of Orthopedics pays non établi dans la noticeUniversité ou école supérieure
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First People's Hospital of Yunnan Province pays non établi dans la noticeÉtablissement de santé
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Second People's Hospital of Yunnan Province pays non établi dans la noticeÉtablissement de santé
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Kunming Medical University pays non établi dans la noticeUniversité ou école supérieure
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China Agricultural University Department of Nutrition and Health pays non établi dans la noticeUniversité ou école supérieure
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Tsinghua University MOE Key Laboratory of Bioinformatics pays non établi dans la noticeUniversité ou école supérieure
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Peking Union Medical College Hospital Department of Orthopedics Surgery pays non établi dans la noticeÉtablissement de santé
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School of Basic Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Orthopedics — Kunming University of Science and Technology, First People's Hospital of Yunnan Province et Second People's Hospital of Yunnan Province, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.