Microwave-synthesized Pd-Fe bimetallic oxide nanozymes for synergistic photothermal/catalytic therapy against bacteria infection and metastatic tumors

Le résumé fourni par la source

The integration of photothermal and chemokinetic therapies has considerable advantages in antimicrobial and anti-tumor treatment. Noble metal nanozymes have attracted much attention owing to their excellent photothermal characteristics and certain catalytic abilities. However, noble metals face challenges such as high cost, poor water-dispersibility, and unstable catalytic activity. To address these issues, we developed ultrasmall Pd-Fe oxide nanoparticles (PdFeO x NPs) through a one-step microwave-assisted solvothermal method. These NPs exhibited uniform morphology, small particle size, excellent aqueous dispersibility, and favorable biocompatibility, which are conducive to biological applications. More importantly, Pd 1 Fe 1 O x with the best nanozyme catalytic performance was successfully prepared by optimizing the Pd and Fe source feeding ratio and reaction conditions. These NPs demonstrated excellent peroxidase (POD)-like and glutathione peroxidase (GPx)-like activities and remarkable photothermal properties with 70.71% photothermal conversion efficiency. These comprehensive properties could effectively induce the glutathione depletion and ROS burst of cancer cells and bacteria, thereby disrupting their antioxidant defense mechanism. As a result, PdFeO x NPs could highly induce thermal ablation of cancer cells and bacteria under laser irradiation. Therefore, this work presents a rapid and straightforward microwave-assisted synthesis method for producing metallic oxide nanozymes, offering promising applications in anti-tumor and antimicrobial therapy.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.