Multicentric Surveillance of Antimicrobial Resistance to Generate Data-Driven Regional Antibiograms: A Laboratory-Based Cross-Sectional Study in Pakistan
Rattachement africain : pk, my, hu, gb, ca, sa. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: The escalating burden of antimicrobial resistance (AMR) poses a critical threat to public health in Pakistan, with rates of high antibiotic consumption and limited standardized surveillance on AMR rates. Our study aimed to carry out a multicentric surveillance of AMR to generate regional antibiograms for Northern Punjab, Pakistan, to guide empirical antimicrobial therapy and stewardship efforts. Methods: A laboratory-based, retrospective cross-sectional study was conducted over a six-month period across three tertiary care hospitals. Socio-demographic, clinical, and microbiological data (including specimen type and antibiotic prescription rates) were collected from N = 485 patients with confirmed bacterial infections. Antimicrobial susceptibility testing was performed based on Clinical Laboratory Standards Institute (CLSI) recommendations. Statistical analyses were carried out using SPSS v.22.0. Results: In our study setting, Gram-positive bacteria were common causes (60.0%) of infections, with Staphylococcus aureus (12.2%) and Streptococcus pneumoniae (10.3%) being the most relevant. Among Gram-negative bacteria (40.0%), Escherichia coli (14.0%) and Pseudomonas aeruginosa (5.8%) were shown to be important pathogens. Overall, 25.0% of S. aureus isolates were methicillin-resistant (MRSA), while ~30% of E. coli showed resistance to third-generation cephalosporins (3GCs). Enterobacterales species had highly variable susceptibility rates (40–70%) for fluoroquinolones. Meropenem and vancomycin/linezolid retained high efficacy (>90%) against most Gram-negative and Gram-positive isolates, respectively. In all healthcare settings studied, ceftriaxone was the most frequently prescribed antibiotic. Conclusions: High levels of resistance against first-line antibiotics were noted in our setting of Northern Punjab, Pakistan, underscoring the critical need for robust antimicrobial stewardship programs, tailored to local institutional contexts, capabilities, and needs. The regional antibiogram developed based on our data may provide vital evidence for informing local empirical treatment guidelines, which need to be continuously updated.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multicentric Surveillance of Antimicrobial Resistance to Generate Data-Driven Regional Antibiograms: A Laboratory-Based Cross-Sectional Study in Pakistan
- Date Crossref
- 14/11/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Lahore Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Mahsa University pays non établi dans la noticeUniversité ou école supérieure
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Capital University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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IMU University pays non établi dans la noticeUniversité ou école supérieure
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University of Szeged pays non établi dans la noticeUniversité ou école supérieure
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University of Nottingham pays non établi dans la noticeUniversité ou école supérieure
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University of Alberta pays non établi dans la noticeUniversité ou école supérieure
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King Saud University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy and Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Pharmacy Department of Pharmacy Practice pays non établi dans la noticeUniversité ou école supérieure
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Albert Szent-Györgyi Faculty of Medicine Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
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University Park Campus Department of Pharmacy Practice and Policy pays non établi dans la noticeUniversité ou école supérieure
Department of Pharmacy — University of Lahore, Mahsa University et Capital University of Science and Technology, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.