Documentation of Advance Care Planning in Early Phase Cancer Clinical Trials: An Australian Single-Centre Experience
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Le résumé fourni par la source
BACKGROUND/OBJECTIVES: Patients with incurable cancers enrolled in early phase clinical trials often face uncertainty about prognosis, yet advance care planning (ACP) is frequently delayed. The objective of this study was to assess the documentation of ACP discussions among patients enrolled in early phase oncology trials. METHODS: We conducted a retrospective review of electronic medical records for all adults enrolled in early phase clinical trials at a single Australian institution (2012-2021). Data included time from metastatic diagnosis to first ACP discussion, clinical and sociodemographic factors, triggers for discussion, and clinician specialty. RESULTS: Among 170 patients (58% male; median age 65 years), ACP documentation was identified in 109 (64%). ACP was most often initiated within the final year of life (73.8%), with a median interval of 23.5 months from metastatic diagnosis to first documentation. Common triggers were disease progression (39.6%) and hospital admission (37.8%). Discussions were typically led by the treating oncologist or trials specialist (43%) and palliative care physician (37.8%). The most frequently documented topic was the limitations of invasive care such as intubation (60%). CONCLUSIONS: ACP documentation was present in two-thirds of patients enrolled in early phase clinical trials, typically late in the disease trajectory. Integrating structured, earlier ACP discussions into oncology pathways would improve alignment of care with patient goals and enhance end-of-life care.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Documentation of Advance Care Planning in Early Phase Cancer Clinical Trials: An Australian Single-Centre Experience
- Date Crossref
- 14/11/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Liverpool Hospital Liverpool Cancer Therapy Centre pays non établi dans la noticeÉtablissement de santé
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Macquarie University pays non établi dans la noticeUniversité ou école supérieure
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UNSW Sydney pays non établi dans la noticeUniversité ou école supérieure
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Ingham Institute pays non établi dans la noticeOrganisation à but non lucratif
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Western Sydney University Liverpool Clinical School pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
Liverpool Cancer Therapy Centre — Liverpool Hospital, Macquarie University et UNSW Sydney, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.