Utility of REMS-Derived Fragility Score and Trabecular Bone Score in Evaluating Bone Health in Type 2 Diabetes Mellitus
Rattachement africain : it, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background/Objectives: A significantly higher fracture risk characterizes Type 2 diabetes mellitus (T2DM) patients when compared to the non-diabetic population, even though their average bone mineral density (BMD) tends to be normal or high. This elevated risk is primarily driven by defective bone quality. The trabecular bone score (TBS) and radiofrequency echographic multispectrometry (REMS) have recently been proposed to improve the assessment of bone quality in T2DM individuals. This study aimed to evaluate whether TBS and REMS can improve the identification of osteoporosis and fracture risk in these patients. Methods: BMD was measured in 223 consecutive T2DM patients (126 women and 97 man) and 102 controls. BMD values for the lumbar spine (LS), femoral neck (FN), and total hip (TH) were obtained via both dual-energy X-ray absorptiometry (DXA) and radiofrequency echographic multi-spectrometry (REMS). In all patients, TBS and Fragility Score (FS) by REMS were measured and prior major osteoporotic fractures (MOF) were assessed. Results: All BMD T-scores measured by REMS were significantly lower than those obtained by DXA at both lumbar and femoral sites. T2DM patients with previous MOF exhibited lower T-scores for both BMD-LS and BMD-TH, as assessed by DXA and REMS, compared with patients without fractures. However, these differences reached statistical significance for BMD-TH with both techniques and for BMD-LS with REMS, but not for BMD-LS with DXA. Moreover, patients with a history of MOF had significantly lower TBS values (p < 0.05) and significantly higher FS values at both lumbar (p < 0.05) and femoral (p < 0.01) sites compared with those without fractures. Conclusions: The results of this study suggest that the parameters obtained using REMS technology (BMD and FS) may be valuable tools for improving the diagnosis of osteoporosis and assessing fracture risk in patients with T2DM.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Utility of REMS-Derived Fragility Score and Trabecular Bone Score in Evaluating Bone Health in Type 2 Diabetes Mellitus
- Date Crossref
- 13/11/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
University of Siena Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Ospedale San Giuseppe pays non établi dans la noticeÉtablissement de santé
-
Université Côte d'Azur pays non établi dans la noticeUniversité ou école supérieure
-
Centre Hospitalier Universitaire de Nice pays non établi dans la noticeÉtablissement de santé
-
Istituto di Fisiologia Clinica pays non établi dans la noticeStructure de recherche
-
National Research Council pays non établi dans la noticeOrganisation à but non lucratif
-
San Giuseppe Hospital Division of Internal Medicine I pays non établi dans la noticeÉtablissement de santé
-
University Hospital of Nice Department of Geriatrics pays non établi dans la noticeUniversité ou école supérieure
-
Institute of Clinical Physiology pays non établi dans la noticeStructure de recherche
Department of Medicine — University of Siena, Ospedale San Giuseppe et Université Côte d'Azur, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.