The Association Between Stress Hyperglycemia Ratio and Short‐Term Outcomes After Successful Recanalization by Mechanical Thrombectomy in Acute Ischemic Stroke Patients

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OBJECTIVE: Transient hyperglycemia, known as stress-induced hyperglycemia, often occurs after acute ischemic events. This study aims to examine the relationship between stress hyperglycemia (SHG) and short-term outcomes following successful recanalization by mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS), providing evidence for predicting short-term prognosis. METHODS: This study included AIS patients who underwent MT and achieved successful recanalization between July 2018 and October 2023 at Northern Jiangsu People's Hospital. Stress hyperglycemia ratio (SHR) was calculated using fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) levels at admission to measure SHG. The primary outcome was a poor prognosis at 90 days. Secondary outcomes included early neurological deterioration (END), hemorrhagic transformation (HT), symptomatic intracranial hemorrhage (sICH), and 90-day death. Multivariable logistic regression analysis was performed to evaluate the association between SHR and short-term prognosis. RESULTS: A total of 394 patients were enrolled. The poor prognosis group had significantly higher SHR than the favorable prognosis group [1.00 (0.87, 1.22) versus 0.82 (0.70, 0.99); p < 0.001]. Multivariable logistic regression analysis confirmed that SHR was independently associated with poor prognosis at 90 days (p < 0.05). CONCLUSION: SHR is associated with both the severity of the condition at admission and a 90-day poor prognosis in AIS patients after successful recanalization by mechanical thrombectomy.

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