P177 Double jeopardy: escalating mortality trends and disparities in lung cancer patients with sepsis – a retrospective epidemiological study
Rattachement africain : Égypte, pk, gb, in, iq, bd. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Lung cancer (LC) remains the leading cause of cancer-related mortality globally. Studies indicate LC patients with sepsis have significantly lower survival rates, yet the temporal trends and disparities in mortality remain unexplored. We examined mortality trends and disparities of LC complicated by sepsis across different sociodemographic strata. Methods This retrospective study analysed death certificate data from the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research database from 1999–2023, for individuals ≥25 years with multiple causes of death listed as lung/bronchus cancer (ICD-10: C34) with sepsis. Age-adjusted mortality rates (AAMRs) per 100,000 population were calculated and stratified by sex, race/ethnicity, and geographic region, with Joinpoint regression analysis to determine the change in mortality trends. Results From 1999–2023, 103,907 deaths were attributed to LC with co-existing sepsis, demonstrating increasing mortality trends throughout the study period. AAMRs rose significantly from 1.61 in 1999 to 2.07 in 2023 (AAPC: 1.32%; p<0.000001). Sex-stratified analysis revealed men had consistently higher overall AAMRs (2.32/100,000) with an AAPC of 0.49% (95% CI: -0.12 to 1.12; p=0.12) compared to women (1.37/100,000) with an AAPC of 1.94% (95% CI: 1.74 to 2.14; p<0.000001). Patients aged ≥65 years exhibited the highest mortality rates (6.59%). Racially, non-Hispanic (NH) Black individuals had the highest overall AAMRs with increasing mortality patterns (AAMRs: 2.57/100,000; AAPC: 0.32%; 95% CI: 0.045 to 0.599; p=0.02), while Hispanic populations recorded the lowest AAMR (1.01/100,000; AAPC: 0.61%; 95% CI: 0.156 to 1.068; p=0.01). Regionally, the South demonstrated the highest mortality (AAMRs: 2.04), followed by the Northeast (AAMRs: 1.78), Midwest (AAMRs: 1.75), and West (AAMRs: 1.42). Most deaths occurred in inpatient medical facilities (90,425 deaths; 87%). Conclusion Mortality rates increased significantly over the study period with a significant increase during recent years. Notable disparities across sex, race/ethnicity, and geographic regions were observed, with NH Black populations and Southern states showed highest mortality rates. These findings highlight the urgent need for targeted sepsis prevention protocols in LC patients, enhanced surveillance systems for high-risk demographics, and comprehensive region-specific interventions to address underlying healthcare disparities and improve clinical outcomes across all populations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- P177 Double jeopardy: escalating mortality trends and disparities in lung cancer patients with sepsis – a retrospective epidemiological study
- Date Crossref
- 01/11/2025
- Éditeur
- BMJ Publishing Group Ltd and British Thoracic Society
- Type
- proceedings-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Alexandria University Égypte (code pays fourni par la source)Université ou école supérieure
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Punjab Medical College pays non établi dans la noticeUniversité ou école supérieure
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Allied Hospital pays non établi dans la noticeÉtablissement de santé
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Papworth Hospital Cardiothoracic Surgery and Transplant Department pays non établi dans la noticeÉtablissement de santé
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Guy's and St Thomas' NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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King Edward Memorial Hospital and Seth G.S. Medical College pays non établi dans la noticeUniversité ou école supérieure
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Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Kufa pays non établi dans la noticeUniversité ou école supérieure
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Dhaka Medical College and Hospital pays non établi dans la noticeUniversité ou école supérieure
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Shrewsbury and Telford Hospital NHS Trust pays non établi dans la noticeÉtablissement de santé
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Alexandria Faculty of Medicine Égypte (pays nommé en fin d’affiliation)Université ou école supérieure
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Faisalabad Medical University Allied Hospital pays non établi dans la noticeUniversité ou école supérieure
Alexandria University (Égypte), Punjab Medical College et Allied Hospital, avec 9 autres affiliations. Pays d’affiliation : Égypte.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.