Neonatal management of parvovirus B19-induced hydrops fetalis: a case report
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Le résumé fourni par la source
Background: Hydrops fetalis (HF) is a severe fetal condition, and congenital Parvovirus B19 (B19V) infection is a leading cause of the non-immune form (NIHF). The recent European B19V outbreak has had a substantial impact on obstetric and neonatal outcomes, leading to an increase in fetal anemia, NIHF, spontaneous abortions, and intrauterine demise. While prenatal diagnosis and intrauterine interventions are well established, postnatal management of B19V-related NIHF remains challenging and outcomes are often poor. Case presentation: We report a preterm newborn with B19V-associated NIHF following intrauterine transfusions for severe fetal anemia. At birth, the neonate had generalized edema, ascites, and respiratory compromise. Despite aggressive medical management, the patient developed persistent, refractory edema. Intervention: Given the failure of conservative therapy, peritoneal dialysis (PD) was initiated as a rescue strategy. PD allowed gradual interstitial fluid removal, microcirculatory recovery, and functional "renal rest" after prolonged pharmacologic stress. Outcome: The neonate progressively improved, with resolution of edema, normalization of renal function, and successful respiratory weaning. At 12 months of corrected age (CA), neurodevelopmental milestones were appropriate, although ongoing long-term surveillance is warranted. Conclusion: This case contributes to the limited evidence on postnatal management of B19V-related NIHF. PD may be considered in neonates with persistent, refractory edema despite maximal conventional therapy, with careful individualization of treatment. Further research, including multicenter registries and controlled studies, is needed to define its role within standardized neonatal care protocols.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neonatal management of parvovirus B19-induced hydrops fetalis: a case report
- Date Crossref
- 11/11/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Siena Clinical Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Universitaria Senese pays non établi dans la noticeÉtablissement de santé
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Ospedale Papa Giovanni XXIII pays non établi dans la noticeÉtablissement de santé
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University of Milano-Bicocca pays non établi dans la noticeUniversité ou école supérieure
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Department of Neonatology pays non établi dans la noticeInstitution
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Milano-Bicocca University Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Department of Obstetrics and Gynecology pays non établi dans la noticeInstitution
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Department of Pediatric Surgery pays non établi dans la noticeInstitution
Clinical Pediatrics — University of Siena, Azienda Ospedaliera Universitaria Senese et Ospedale Papa Giovanni XXIII, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.