The association between dietary iron intake and the incidence of cardiometabolic multimorbidity: the mediating role of biological age
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Le résumé fourni par la source
BACKGROUND: We aimed to examine whether dietary iron intake is associated with cardiometabolic multimorbidity (CMM) incidence and the potential role of biological age in mediating this association. METHODS: Based on data from the 2009 China Nutrition and Health Survey (CHNS), a national prospective cohort study of the Chinese population. Dietary intake was calculated from three consecutive 24-hour dietary recalls and household food stocks. CMM was defined as the presence of at least two cardiometabolic diseases (hypertension, diabetes, stroke, and myocardial infarction). Biological aging indicators included Klemera-Doubal method (KDM), phenotypic age (PA), homeostatic dysregulation (HD), and adaptive load (AL). Data were analyzed using COX risk regression, restricted cubic spline method (RCS) analysis and subgroup analysis. Mediation analysis was used to explore the mediating role of biological aging. RESULTS: : 0.69, 95%CI: 0.53-0.90) were associated with a lower risk of developing CMM. Compared to the age deceleration group, all age acceleration groups were associated with a significantly higher incidence of CMM, with hazard ratios of 3.41 (95% CI: 2.95-3.95) for KDM, 3.36 (95% CI: 2.88-3.92) for PA, 4.33 (95% CI: 3.55-5.28) for HD, and 3.42 (95% CI: 2.91-4.03) for AL. Total dietary iron intake and dietary non-heme iron intake were U-shapedly correlated with biological age (P for nonlinearity < 0.001). In the total population, significant indirect effects average causal mediation effects of total iron 0.03% (95% CI: 0.01%-0.04%) and non-heme iron 0.02% (95% CI: 0.01%-0.03%) were exhibited via the KDM algorithm, while heme iron 0.24%-0.45% (95% CI: 0.06%-1.07%) demonstrated significant indirect effects through all four biological age algorithms. CONCLUSION: High dietary iron intake is associated with a lower risk of CMM, partially mediated by biological aging. Appropriate intake of total dietary iron and non-heme iron may be associated with a slowed biological aging process and a lower risk of CMM.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The association between dietary iron intake and the incidence of cardiometabolic multimorbidity: the mediating role of biological age
- Date Crossref
- 10/11/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hubei University of Chinese Medicine Department of Tuina and Rehabilitation Medicine pays non établi dans la noticeUniversité ou école supérieure
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Hubei Provincial Hospital of Traditional Chinese Medicine Department of Tuina and Rehabilitation Medicine pays non établi dans la noticeÉtablissement de santé
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Hubei University Of Economics pays non établi dans la noticeUniversité ou école supérieure
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School of Nursing pays non établi dans la noticeUniversité ou école supérieure
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Hubei Institute of Traditional Chinese Medicine Department of Tuina and Rehabilitation Medicine pays non établi dans la noticeStructure de recherche
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Hubei Shizhen Laboratory pays non établi dans la noticeStructure de recherche
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First Clinical Medical College pays non établi dans la noticeUniversité ou école supérieure
Department of Tuina and Rehabilitation Medicine — Hubei University of Chinese Medicine, Department of Tuina and Rehabilitation Medicine — Hubei Provincial Hospital of Traditional Chinese Medicine et Hubei University Of Economics, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.