The impact of weight change on mortality and cardiovascular outcomes in obstructive sleep apnea
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Le résumé fourni par la source
STUDY OBJECTIVES: Weight is related to the severity of obstructive sleep apnea (OSA), but the impact of weight and its change on prognosis remains unclear. This study aimed to investigate the association between weight, weight change, and mortality in participants with OSA. METHODS: This cohort study investigated participants with OSA from the Sleep Heart Health Study (SHHS). Participants were grouped according to body mass index (BMI) at SHHS1 and the percent difference in body weight between SHHS1 and SHHS2. The weight change patterns were defined as: weight loss (lost ≥ 2.5%), stable weight (changed < 2.5%), and weight gain (gained ≥ 2.5%). The association between weight, weight change with mortality, and cardiovascular outcomes were analyzed. RESULTS: Of 1525 participants, with a median age of 65 years at SHHS1, weight was positively correlated with the severity of OSA, but higher risk was seen in lean participants (BMI < 25 kg/m2) for all-cause mortality. From SHHS1 to SHHS2, the burden of OSA decreased in the weight loss group and increased in the weight gain group. With a median follow-up of 6.6 years since SHHS2, weight loss increased the risk of all-cause and cardiovascular diseases mortality (hazard ratio [95% CI]: 1.370 [1.019, 1.841] and 1.700 [1.024, 2.823]), while weight gain reduced the risk of adverse outcomes, compared to participants with stable weight. CONCLUSIONS: Among middle-aged and elderly participants with OSA, weight loss reduced the burden of OSA, but increased the risk of mortality. For this population, a risk-based approach may be necessary to guide individualized weight management. Statement of Significance Weight loss reduced the burden of OSA, but was associated with an increased risk of all-cause and CVD mortality. For patients with OSA, especially in the middle-aged and elderly population, undifferentiated recommendations for weight loss are not advisable. More attention should be paid to factors beyond weight.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The impact of weight change on mortality and cardiovascular outcomes in obstructive sleep apnea
- Date Crossref
- 10/11/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Capital Medical University Beijing Anzhen Hospital pays non établi dans la noticeUniversité ou école supérieure
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National Clinical Research Center for Digestive Diseases pays non établi dans la noticeÉtablissement de santé
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Beijing Anzhen Hospital pays non établi dans la noticeÉtablissement de santé
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Beijing Institute of Water pays non établi dans la noticeStructure de recherche
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Beijing Institute of Heart pays non établi dans la noticeStructure de recherche
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National Clinical Research Center for Cardiovascular Diseases pays non établi dans la noticeStructure de recherche
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Beijing Hospital Department of Cardiology pays non établi dans la noticeÉtablissement de santé
Beijing Anzhen Hospital — Capital Medical University, National Clinical Research Center for Digestive Diseases et Beijing Anzhen Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.