Relationship between trace elements status and atrial fibrillation in patients with valvular heart diseases
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Le résumé fourni par la source
Background Atrial fibrillation (AF) combined with valvular heart disease (VHD) is increasingly prevalent worldwide and is associated with high morbidity and mortality. Studies have showed trace element concentrations varied in patients with AF and may be involved in the pathogenesis of AF. However, no data is currently available for those with VHD. Methods Urine samples as well as clinical data were collected from 72 VHD patients with AF (VHDAF) and 72 VHD patients without AF (VHD) and further analyzed for a panel of trace elements: lithium, manganese, cobalt, copper, zinc, arsenic, selenium, strontium, Cadmium, mercury, thallium, lead. Quantile g-computation was adopted to explore the joint effect of the 12 trace elements on AF in this population, and internal validation was performed using 1,000 bootstrap re-samples. Results Compared with the VHD group, Sr levels were reduced, while Mn, Cu and Hg concentrations were increased in the VHDAF group. Quantile g-computation model indicated a significant association between the mixtures of the 12 urinary trace elements and AF in patients with heart valve disease (adjusted OR: 2.051; 95% CI: 1.180–3.565; p = 0.011). Positive partial effect was owing to Cu (weight: 0.43) and Hg (weight: 0.18), while negative partial effect mainly attributed to Sr (weight: 0.43) and Li (weight: 0.23). Conclusion VHDAF patients had higher Cu levels and lower Sr levels, and the two elements have been supposed to exert the largest influence on AF. Further research is needed to establish the causal relationships.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Relationship between trace elements status and atrial fibrillation in patients with valvular heart diseases
- Date Crossref
- 07/11/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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South China Sea Institute Of Oceanology pays non établi dans la noticeStructure de recherche
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Guangdong Academy of Medical Sciences pays non établi dans la noticeÉtablissement de santé
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Guangdong Provincial People's Hospital pays non établi dans la noticeÉtablissement de santé
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Southern Medical University Department of Cardiac Surgery pays non établi dans la noticeUniversité ou école supérieure
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Sun Yat-sen University Department of Geriatrics pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Provincial Key Laboratory of South China Structural Heart Disease pays non établi dans la noticeStructure de recherche
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School of Public Health (Shenzhen) pays non établi dans la noticeUniversité ou école supérieure
South China Sea Institute Of Oceanology, Guangdong Academy of Medical Sciences et Guangdong Provincial People's Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.