Prevalence and Implications of Plasmodium Falciparum Multidrug Resistance Gene Mutations (PFMDR1) Among Pediatric Patients with Malaria in Kano, Nigeria
Rattachement africain : Nigéria, in. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
A genetic indicator of the parasites' vulnerability to anti-malarial medications is the Plasmodium falciparum multidrug resistance gene 1 (pfmdr1). In this study, malaria patients aged 0–14 who were treated at Murtala Muhammad Specialist Hospital in Kano, Nigeria, were evaluated for multidrug-resistant resistance gene 1 (MDR1) mutations. After confirming the malaria parasite density in 100 children's samples, the samples were genotyped using BigDye (v3.1) terminator cycle sequencing to look for two SNPs in pfmdr1 on samples with high and moderate parasite densities. Fisher's exact (FE) tests and Pearson Chi-square were used to evaluate the data. Of the 100 samples, 57% of the patients had low (+) malaria parasite densities, 28% had moderate (++) densities, and 15% had high (+++) densities. Only seven samples were successfully amplified for the pfmdr1 gene located at codon 1246, whereas 31 were successfully amplified and processed for the pfmdr1 gene located at codon 86 with an amplicon size of 534 bp. A Pfmdr1-N86Y mutation was found in one sample (3.2%). Additionally, the results indicated no correlation (P = 0.4237) between sex and the pfmdr1SNP mutation. Nonetheless, there was a significant correlation (P = 0.0043) between the pfmdr1 mutation and the age groups. According to the current study, Kano state in northern Nigeria may have strains of P. falciparum that are less sensitive to the artemisinin component of artemisinin-based combination therapy (ACT). The Plasmodium falciparum parasites' development of this resistance gene puts malaria chemotherapy at serious risk because the parasite will be immune to the widely prescribed anti-malarial medications.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence and Implications of Plasmodium Falciparum Multidrug Resistance Gene Mutations (PFMDR1) Among Pediatric Patients with Malaria in Kano, Nigeria
- Date Crossref
- 06/11/2025
- Éditeur
- Umaru Musa YarAdua University Katsina NG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Abubakar Tafawa Balewa University Nigéria (code pays fourni par la source)Université ou école supérieure
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Sa'adu Zungur University Nigéria (code pays fourni par la source)Université ou école supérieure
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Gyan Vihar University pays non établi dans la noticeUniversité ou école supérieure
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Bayero University Kano Department of Nursing Sciences Bayero University Kano, Nigéria (code pays fourni par la source)Université ou école supérieure
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Faculty of Basic Medical Sciences Department of Medical laboratory Sciences Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
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Faculty of Allied Health Sciences Department of Nursing Sciences Bauchi, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
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Public Health Department Bauchi State University Bauchi, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
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Faculty of Pharmacy Department of Pharmaceutical pays non établi dans la noticeUniversité ou école supérieure
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Federal University Dutse Department of Community Medicine Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
Abubakar Tafawa Balewa University (Nigéria), Sa'adu Zungur University (Nigéria) et Gyan Vihar University, avec 6 autres affiliations. Pays d’affiliation : Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.