An Insight into Role of Auditory Brainstem in Tinnitus: A Systematic Review of Diagnostic Assessments
Rattachement africain : it, jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background/Objectives: Tinnitus is a complex auditory phenomenon with multifactorial origins, often involving both peripheral and central auditory pathways. Given the multifactorial nature of tinnitus, this review specifically focuses on the auditory brainstem as it represents the first central relay for auditory input and a key site of abnormal synchrony and central gain, which may generate or modulate tinnitus even when peripheral hearing appears normal. Several studies suggest a potential role of brainstem dysfunction in its pathogenesis, even among patients with normal hearing thresholds. Although the physiopathological data provide evidence for the role of brainstem in the generation and magnification of tinnitus, the diagnostic tools are still unclear. This systematic review aimed to investigate the diagnostic relevance of brainstem-level abnormalities in individuals with tinnitus. Methods: Following PRISMA guidelines, a literature search was conducted using PubMed, Scopus, and Web of Science from January 2000 to June 2025. Studies were included if they addressed the diagnostic relationship between tinnitus and brainstem involvement. Data on auditory brainstem response (ABR), otoacoustic emissions (used to differentiate peripheral from central auditory abnormalities), neuroimaging, and electrophysiological markers were extracted. Results: Twenty studies were included. Most used ABR as a diagnostic tool, revealing significant amplitude and latency alterations in tinnitus patients compared to controls, particularly in wave V and V/I amplitude ratios. Imaging studies supported altered brainstem–cortical connectivity and localized changes in inferior colliculus (IC) activity. Additional techniques, such as middle-latency evoked potentials and gap-in-noise detection, showed potential but lacked consistent clinical utility. Conclusions: Evidence suggests that brainstem dysfunction may contribute to tinnitus generation or persistence. ABR and advanced imaging represent specific diagnostic tools, though standardization and high-quality studies are still needed to improve clinical applicability.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- An Insight into Role of Auditory Brainstem in Tinnitus: A Systematic Review of Diagnostic Assessments
- Date Crossref
- 06/11/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Federico II University Hospital Department of Head and Neck pays non établi dans la noticeÉtablissement de santé
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University of Naples Federico II Department of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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University of Ferrara pays non établi dans la noticeUniversité ou école supérieure
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Università Cattolica del Sacro Cuore pays non établi dans la noticeUniversité ou école supérieure
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Agostino Gemelli University Polyclinic pays non établi dans la noticeÉtablissement de santé
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University of the Sacred Heart Department of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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University of Catania Department of Medical pays non établi dans la noticeUniversité ou école supérieure
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Ospedale Madonna Delle Grazie pays non établi dans la noticeÉtablissement de santé
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University Hospital of Ferrara Department of Neuroscience and Rehabilitation pays non établi dans la noticeUniversité ou école supérieure
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Foundation Polyclinic University A. Gemelli IRCCS Department of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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Department of Otorhinolaryngology and Cervico-Facial Surgery pays non établi dans la noticeOrganisation à but non lucratif
Department of Head and Neck — Federico II University Hospital, Department of Neuroscience — University of Naples Federico II et University of Ferrara, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.