Design and Targeting Strategies in Nanotheranostics for Glioma

Le résumé fourni par la source

Glioma is a highly aggressive brain tumor with a poor prognosis and limited therapeutic efficacy. Nanotheranostics, integrating diagnostic and therapeutic functions, offer a promising strategy for precise and effective glioma management. This review summarizes recent advances in the rational design of nanotheranostic systems, including glioma-specific biomarkers, engineered nanocarriers, and stimuli-responsive strategies to enhance delivery across the blood-brain barrier and improve tumor targeting. We also discuss challenges posed by tumor heterogeneity and the glioma blood-brain barrier. Furthermore, we highlight advanced nanomedicine-based imaging modalities, including magnetic resonance imaging, fluorescence imaging, photoacoustic imaging, and nuclear imaging, along with therapeutic approaches such as chemotherapy, radiotherapy, gene therapy, and immunotherapy. Collectively, these developments underscore the potential of nanotheranostics in achieving a personalized and multimodal treatment of glioma.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.