Increased high-risk plaque burden in type 2 diabetes: a 10-year follow-up study

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BACKGROUND: Using serial coronary CT angiography (CCTA) imaging, we aimed to characterize baseline coronary plaque characteristics and quantify 10-year coronary plaque progression, including high-risk and low-density plaque presence, in patients with and without type 2 diabetes. METHODS: A total of 299 patients underwent CCTA with a median scan interval of 10.2 [IQR 8.7-11.2] years. Patients who underwent coronary artery bypass grafting and vessels revascularized by percutaneous coronary intervention were excluded (n = 32). Scans were analyzed using atherosclerosis imaging-quantitative CCTA analysis (AI-QCT; Cleerly Inc.). Associations between diabetic status, baseline and follow-up plaque burden and characteristics were evaluated using multivariable regression adjusted for cardiovascular risk factors, statin use, baseline plaque volumes, and scanner settings. RESULTS: In total, 267 patients were included (mean age 57 ± 7 years; 43% were women), 44 (16.5%) had type 2 diabetes (HbA1c 56 ± 14 mmol/mol). At baseline, patients with diabetes had a higher percent atheroma volume (PAV) compared to non-diabetic individuals (5.1% [1.7, 10.9] versus 2.2% [0.5, 5.8]). Adjusted for cardiovascular risk factors, patients with diabetes had a higher plaque burden at both baseline and follow-up. After adjustment for cardiovascular risk factors and baseline plaque volumes, individuals with diabetes had a more than threefold higher rate of plaque progression. After 10 years of follow-up, patients with diabetes had a higher prevalence of both high-risk plaque (OR 2.75; 95% CI 1.38-5.48; p = 0.004) and low-density plaque (OR 2.88; 95% CI 1.45-5.70; p = 0.002). CONCLUSIONS: Patients with diabetes had a more than threefold higher rate of coronary plaque progression and an increased development of high-risk plaque.

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