Association of Vibration Perception Threshold with Biochemical Markers, Body Composition, and Family History of Diabetes Mellitus

Le résumé fourni par la source

Background: Peripheral neuropathy, especially diabetic peripheral neuropathy (DPN), is a common complication of diabetes.Obesity, particularly visceral fat, is an emerging risk factor, especially in young Indians, where body mass index (BMI) may underestimate risk.Bioelectrical impedance analysis (BIA) provides a better assessment of body composition.Vibration perception threshold (VPT) testing is a noninvasive method for early neuropathy detection.Objectives: To evaluate the relationship between body composition and VPT in healthy young adults and assess the influence of a family history (FH) of diabetes mellitus (DM). Materials and methods:In this cross-sectional study, 200 MBBS students were grouped based on FH of DM (n = 100 each).Anthropometric measurements, glucose levels, HbA1c, and BIA parameters were recorded.VPT was assessed at 12 plantar sites using a digital biothesiometer.Data were analyzed using t-tests and Pearson's correlation.Observations and results: The FH group had significantly higher HbA1c (p = 0.015), postprandial blood glucose (PPBG) (p = 0.001), muscle mass, bone mass, and total body water.VPT was higher in the FH group (p = 0.059).VPT positively correlated with HbA1c (r = 0.21), BMI (r = 0.223), and bone mass (r = 0.202).Conclusion: Elevated VPT in young individuals with FH of DM may indicate early subclinical neuropathy.BIA and VPT could aid in early risk detection and intervention.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.