Association of biliary microflora dysbiosis with cholangiocarcinoma: a single-center study
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Le résumé fourni par la source
Background: Cholangiocarcinoma (CCA) is an aggressive malignancy that poses a serious threat to long-term survival. In this study, we compared the biliary microbiota and metabolomic profiles of patients with CCA and those with choledocholithiasis to identify characteristic microbial species and metabolites associated with CCA and to explore the mechanisms linking microbial dysbiosis to CCA development. Methods: A total of 25 CCA patients and 25 choledocholithiasis patients were included in the study. Bile was collected intraoperatively and analyzed using 16S rRNA sequencing and liquid chromatography-mass spectrometry (LC-MS) to investigate the correlation between specific microorganisms and metabolites by integrating microbiomics and metabolomics. Results: The abundance and diversity of microorganisms were similar between the two groups; however, their microbial compositions were significantly different. Microbial-metabolite interactions may contribute to CCA development through pathways such as inflammation, oxidative stress, and energy metabolism. Conclusion: These findings reveal a unique microbial community structure and metabolic profiles in CCA patients, providing potential microbial and metabolic markers for early CCA diagnosis. They also lay a theoretical foundation for the development of novel therapeutic strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association of biliary microflora dysbiosis with cholangiocarcinoma: a single-center study
- Date Crossref
- 03/11/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Fuyang Second People's Hospital pays non établi dans la noticeÉtablissement de santé
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Wannan Medical College Graduate School pays non établi dans la noticeÉtablissement de santé
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Fuyang City People's Hospital pays non établi dans la noticeÉtablissement de santé
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The Affiliated Fuyang Hospital of Bengbu Medical University Department of Hepatobiliary and Pancreatic Surgery pays non établi dans la noticeUniversité ou école supérieure
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Fuyang People's Hospital Department of Hepatobiliary and Pancreatic Surgery pays non établi dans la noticeÉtablissement de santé
Fuyang Second People's Hospital, Graduate School — Wannan Medical College et Fuyang City People's Hospital, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.