Effects of Mulberry Leaf and Corn Silk Extracts Against α-Amylase and α-Glucosidase In Vitro and on Postprandial Glucose in Prediabetic Individuals: A Randomized Crossover Trial
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Le résumé fourni par la source
OBJECTIVE: Postprandial hyperglycemia is a major risk factor for type 2 diabetes and cardiovascular disease. Inhibition of α-amylase and α-glucosidase can attenuate postprandial glycemic response (PPGR). This study aimed to investigate the inhibitory effects of mulberry leaf and corn silk on these enzymes in vitro and their impact on postprandial glucose (PG) levels in prediabetic individuals using milk-based matrices. RESEARCH DESIGN AND METHODS: In vitro, enzyme inhibition was assessed using the DNS method (α-amylase) and pNPG method (α-glucosidase). A randomized crossover trial was conducted in 11 prediabetic individuals with four interventions: pure milk; lactose-hydrolyzed milk; lactose-hydrolyzed milk with mulberry leaf, corn silk, and resistant dextrin; and GOS milk with mulberry leaf and corn silk. PPGR was assessed by area under the glucose curve, 1 and 2 h PG, maximum PG, and 2 h glucose excursion. Paired Wilcoxon signed-rank tests were used for comparisons. RESULTS: Mulberry leaf and corn silk extracts inhibited both enzymes dose-dependently, with synergistic effects. No significant differences in PPGR indices were observed across interventions in the overall prediabetic individuals. However, in the overweight subgroup, the combination of GOS milk supplemented with mulberry leaf and corn silk significantly reduced 1 h PG (median difference [P25, P75]: -0.84 mmol/L [-1.05, -0.49]), maximum PG (-0.54 mmol/L [-0.75, -0.25]), and glucose excursion (-0.62 mmol/L [-0.75, -0.24]) compared to pure milk. CONCLUSIONS: Mulberry leaf and corn silk extracts inhibit α-amylase and α-glucosidase in vitro and may attenuate postprandial glucose excursions in overweight prediabetic individuals when delivered in a GOS milk matrix.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of Mulberry Leaf and Corn Silk Extracts Against α-Amylase and α-Glucosidase In Vitro and on Postprandial Glucose in Prediabetic Individuals: A Randomized Crossover Trial
- Date Crossref
- 31/10/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tianjin University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Education pays non établi dans la noticeOrganisme public
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China Agricultural University Key Laboratory of Precision Nutrition and Food Quality pays non établi dans la noticeUniversité ou école supérieure
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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National Health and Family Planning Commission pays non établi dans la noticeOrganisme public
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Peking Union Medical College Hospital Key Laboratory of Endocrinology of National Health Commission pays non établi dans la noticeÉtablissement de santé
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College of Food Science and Engineering pays non établi dans la noticeUniversité ou école supérieure
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National Center of Technology Innovation for Dairy pays non établi dans la noticeInstitution
Tianjin University of Science and Technology, Ministry of Education et Key Laboratory of Precision Nutrition and Food Quality — China Agricultural University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.