Abstract 4339399: Incidence and predictors of Monomorphic Ventricular Tachycardia in Three Major Subcutaneous ICD Trials
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Le résumé fourni par la source
Background: The subcutaneous ICD (S-ICD) is currently contraindicated for patients (pts) who have monomorphic ventricular tachycardia (MVT) that can be terminated by anti-tachycardia pacing (ATP). Discriminating S-ICD pts who subsequently present with MVT can help identify those who would benefit from a transvenous ICD or upgrade to an investigational, modular leadless pacemaker/S-ICD system to deliver anti-tachycardia pacing. Objective: Identification of burden and determinants of MVT in S-ICD recipients. Methods: Pooled data from 3 S-ICD studies: EFFORTLESS (N=994), S-ICD PAS (N=1643), and UNTOUCHED (N=1116) were analyzed. All MVT episodes of all cycle lengths (treated with ≥1 shock and untreated: self-terminated or rate Results: A total of 3753 pts was followed for 3.6 years (median). Of these, 549 (14.6%) experienced >1 MVT episode (table). Age was 54±15 years, 80% male, 77% primary prevention, and EF 32±15%. Of these 549 pts, 373 pts experienced ≥2 episodes, with median time between 1 st and 2 nd episode 102 (interquartile range 6,391) days. The 5-year rate of experiencing MVT was 20% with shock therapy in 11% (fig1). A total of 298 pts (7.9%) experienced ≥1 shock in 804 episodes, 7% pts had ≥1 shocks for fast MVT (>200bpm), and 52 pts (1.4%) experienced 67 storms (≥3 episodes/24 hours). S-ICD extraction due to the need for ATP pacing was reported for only 10 (0.3%) patients While several baseline variables were identified as a risk of MVT, the multivariable predictor model indicated that pts who experienced MVT were more likely to have a lower ejection fraction and less likely to have diabetes (fig2). Risk of MVT across EF quartiles differed by ≤4.1% with EF 30-35% having the most events and presence of diabetes differed by ≤2.1%, respectively, across all time points. Conclusions: Over 5 years, 11% of S-ICD patients from EFFORTLESS, S-ICD PAS, and UNTOUCHED studies experienced shock therapy for MVTs, and 20% of patients had MVT (treated and untreated). Conversion rate to TV-ICD for ATP was low. Surprisingly, many of the expected risk factors for MVT were not predictive of MVT, which may be in part due to proper exclusion of patients with a MVT in S-ICD studies. Further detailed analysis of univariable predictor and MVT features could help inform device prescription.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Abstract 4339399: Incidence and predictors of Monomorphic Ventricular Tachycardia in Three Major Subcutaneous ICD Trials
- Date Crossref
- 04/11/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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University College Hospital at Westmoreland Street pays non établi dans la noticeÉtablissement de santé
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University College London pays non établi dans la noticeUniversité ou école supérieure
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Medical University of South Carolina pays non établi dans la noticeUniversité ou école supérieure
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University College Hospital at Westmoreland Street, University College London et Medical University of South Carolina, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.