IL-6 and TNF variants as potential determinants of perianal disease in Crohn's patients: a pilot study
Rattachement africain : by, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Perianal Crohn's disease (pCD) is a debilitating complication of Crohn's disease (CD), affecting approximately 20 % of patients. Genetic polymorphisms in cytokine-related and intracellular signaling pathway genes may influence pCD development, yet data on their role remain limited. To evaluate the association between specific single nucleotide polymorphisms (SNPs) in cytokine (TNF, IL-6, IL-10, TGF-β) and MAPK pathway-related genes (RAS, RAF-1, ERK) and the pCD development. This retrospective study included 204 CD patients from a single center, of whom 34 had documented pCD. Clinical, phenotypic, and treatment data were collected. Genotyping was performed by real-time PCR and ARMS-PCR. IL-6 -597 GG genotype was significantly associated with a reduced risk of pCD (p = 0.049). TNF rs1800629-308 GA genotype showed a trend toward protection (p = 0.07). IL-10 -1082 AA genotype showed a non-significant trend toward increased risk (p = 0.07). No significant associations were found for TGF-β or MAPK-related polymorphisms. Our findings suggest that polymorphisms in cytokine genes, particularly IL-6 and TNF, may influence the risk of developing perianal complications in CD. These preliminary results warrant validation in larger cohorts to assess their potential as predictive biomarkers for personalized management of pCD.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- IL-6 and TNF variants as potential determinants of perianal disease in Crohn's patients: a pilot study
- Date Crossref
- 01/12/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Department of Medical Sciences pays non établi dans la noticeStructure de recherche
-
University of Turin Department of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino pays non établi dans la noticeÉtablissement de santé
-
Ospedale Amedeo di Savoia pays non établi dans la noticeÉtablissement de santé
-
Città della salute e della Scienza Hospital Gastroenterology-U pays non établi dans la noticeÉtablissement de santé
-
Amedeo di Savoia Hospital SCDU Infectious Diseases pays non établi dans la noticeÉtablissement de santé
Department of Medical Sciences, Department of Medical Sciences — University of Turin et Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.