Neural network tissue and myocytes co-culture system reveals effects of different myocytes on postnatal development of spinal cord neural network
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Le résumé fourni par la source
The spinal cord serves as a vital bridge connecting the brain and all the organs of the body, and its development and function are affected by other organs [ 1 , 2 , 3 ]. The interaction between the spinal cord neural network and myocytes is essential for the development and maturation of the nervous system, and is closely related to somatic movement and visceral functions [ 4 , 5 ]. Skeletal muscle cells (SkMCs) are innervated by spinal cord motor neurons [ 2 ], and vascular smooth muscle cells in central nervous tissue and corpus cavernosum smooth muscle cells (CC-SmMCs) are also innervated by spinal cord neuron [ 6 , 7 ]. There have been studies on the interaction between central nervous system (CNS) organoids and SkMCs, which simulate the impact of skeletal muscle on the development and functional formation of the CNS during the early stages of development [ 8 , 9 ]. However, little is known about the mechanism by which SkMCs and CC-SmMCs, influence the postnatal development of the spinal cord neural network [ 10 ]. In contrast to the embryonic stage, postnatal development of the central nervous system relies more heavily on the refinement of synaptic activity and the feedback regulation of neural function by muscle activity [ 11 ]. Given that the maturation of neural circuits and neuromuscular junctions predominantly occurs during the postnatal period, investigating normal postnatal neuromuscular development is essential for understanding pediatric neuromuscular disorders such as cerebral palsy, spinal muscular atrophy (SMA), and muscular dystrophies [ 12 ]. Therefore, establishing a spinal cord neuro-myocyte interaction system through tissue engineering technology and exploring the effects of SkMCs or CC-SmMCs on the differentiation and maturation of the spinal cord neural network can help elucidate the mechanisms of postnatal neural development and regeneration or simulate neuromuscular diseases [ 13 , 14 ].
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neural network tissue and myocytes co-culture system reveals effects of different myocytes on postnatal development of spinal cord neural network
- Date Crossref
- 30/10/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sun Yat-sen University Department of Gastrointestinal Surgery pays non établi dans la noticeUniversité ou école supérieure
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Third Affiliated Hospital of Sun Yat-sen University pays non établi dans la noticeÉtablissement de santé
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Guangdong Academy of Medical Sciences pays non établi dans la noticeÉtablissement de santé
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Guangdong Provincial People's Hospital pays non établi dans la noticeÉtablissement de santé
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Nantong University Coinnovation Center of Neuroregeneration pays non établi dans la noticeUniversité ou école supérieure
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Zhongshan School of Medicine Key Laboratory for Stem Cells and Tissue Engineering Ministry of Education pays non établi dans la noticeUniversité ou école supérieure
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Southern Medical University Department of Orthopedics Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Cardiovascular Institute pays non établi dans la noticeStructure de recherche
Department of Gastrointestinal Surgery — Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University et Guangdong Academy of Medical Sciences, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.