Participation of the Periosteum, Endosteum, and Hematogenous Marrow in the Early Osseointegration of a Titanium Implant Inserted in Contact with the Hematogenous Marrow
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Le résumé fourni par la source
Background and Objectives: Implant osseointegration has been widely studied over the past few decades, particularly focusing on surface modifications that aim to improve integration. However, the literature includes few studies regarding the role of the endosteum in early osteointegration. Therefore, the aim of the present work is to approach the technique of implant insertion into bones with marrow, with an emphasis on the use of implants that are long enough to achieve marrow penetration. Materials and Methods: Titanium implants were inserted into the femurs of eight eleven-month-old rabbits. Fourteen days later, the animals were euthanized in accordance with the current legal and ethical guidelines. The histological processes that occur at the bone–implant interface were investigated. Histological sections of the bone–implant interface were colored using the Trichrome’s Goldner method, and were further analyzed and photographed using an Olympus microscope. Results: The histological analysis showed that during the initial osteointegration phases, the newly formed bone originated from the endosteal–medular zone. Periostal proliferation was observed only during the early stages. The bone that proliferated on the implant’s endosteal/medullary interface exhibited a surface area approximately 6 times larger than that of the bone formed on the osteal surface. Also, its length was approximately 25% longer. Conclusions: The bone tissue that proliferates on the endosteal and marrow surface of the implant increases significantly the bone–implant interface, and creates the setting for a good secondary stability. The findings suggest several clinical implications, as follows: penetrating the bone marrow during the insertion of short implants allows for increasing the bone–implant interface; the flap should be carefully managed; the integrity of the periosteum must be kept, as this is a key anatomical structure in cases of deficient bone marrow (i.e., severe mandible atrophy or vertical ridge augmentations).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Participation of the Periosteum, Endosteum, and Hematogenous Marrow in the Early Osseointegration of a Titanium Implant Inserted in Contact with the Hematogenous Marrow
- Date Crossref
- 14/10/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Oradea pays non établi dans la noticeUniversité ou école supérieure
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Victor Babeș University of Medicine and Pharmacy Timișoara pays non établi dans la noticeUniversité ou école supérieure
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Polytechnic University of Timişoara pays non établi dans la noticeUniversité ou école supérieure
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Iuliu Hațieganu University of Medicine and Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine and Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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“Victor Babes” University of Medicine and Pharmacy Timisoara Research Center in Dental Medicine Using Conventional and Alternative Technologies pays non établi dans la noticeUniversité ou école supérieure
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"Victor Babes" University of Medicine and Pharmacy Timisoara Research Center in Dental Medicine Using Conventional and Alternative Technologies pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Electronics Department of Measurements and Optical Electronics pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
University of Oradea, Victor Babeș University of Medicine and Pharmacy Timișoara et Polytechnic University of Timişoara, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.