Electrochemical telescoped synthesis of alkyl pinacol boranes

Le résumé fourni par la source

Abstract Boron-containing compounds are essential building blocks in organic synthesis. A significant advancement in the preparation of alkyl boranes relied on the use of B 2 Cat 2 with competent radical precursors under chemical, photochemical, and electrochemical conditions. However, these molecules are unstable and require one-pot formation of corresponding pinacol boranes to be isolated. In this work, we present a continuous flow electrochemical decarboxylative borylation approach telescoped with the exchange from unstable catechol boranes intermediates to isolable pinacol boranes. The study encompassed the optimization of a single-pass protocol employing an electrochemical microreactor, followed by the telescoped pinacol addition. No supporting electrolyte was necessary to successfully execute the process. The continuous-flow approach was validated across 11 examples comprising primary, secondary, and tertiary alkyl carboxylic acids. Graphical Abstract

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.