Global concerns, local challenges: the alarming spread of FC428-related gonococcal strains in Nanchang City, 2021
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Le résumé fourni par la source
OBJECTIVES: Antimicrobial resistance (AMR) in N. gonorrhoeae is a major global health issue, with most ceftriaxone treatment failures linked to Asian strains, especially FC428-related strains. Since 2019, Nanchang City has participated in World Health Organization’s surveillance program, but local AMR assessments were lacking. This study aimed to examine the AMR profiles and molecular traits of N gonorrhoeae from Nanchang in 2021. METHODS: We used antibiotic susceptibility testing and whole genome sequencing for AMR surveillance, genotyping, resistance gene identification, and evolutionary analysis. RESULTS: In 2021, Nanchang reported resistance rates of 68.5% for penicillin, 81.5% for tetracycline, 100% for ciprofloxacin, 5.6% for azithromycin, 0% for spectinomycin, 13% for ceftriaxone and 20.4% for cefixime. Decreased susceptibility was 16.7% for ceftriaxone. Twelve strains exhibited cephalosporins MICs ≥ 0.125 mg/L, with single-nucleotide polymorphisms in genes like porB, tbpB, penA, mtrR, ponA, gyrA and parC being key contributors to different NG-MAST and NG-STAR genotypes. For MLST, the predominant genotypes were MLST-7365 (n = 5) and MLST-8123 (n = 2), with additional genotypes including MLST-1580, MLST-1903, MLST-7367, MLST-8126, and MLST-15278. Resistance markers like penA mosaic mutations, blaTEM-1, and blaTEM-135 plasmids were detected in cephalosporins and penicillin high-level resistant strains. Among above cephalosporins decreased-susceptible isolates, six strains with penA-60.001 mosaic mutation were found to be related to global FC428-related clones previously, particularly those originating from domestic strains. CONCLUSIONS: The study highlights high AMR rates in N. gonorrhoeae in Nanchang, China, in 2021, particularly strains with decreased cephalosporin susceptibility, threatening their effectiveness as a first-line treatment, likely due to the spread of FC428 subclones.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Global concerns, local challenges: the alarming spread of FC428-related gonococcal strains in Nanchang City, 2021
- Date Crossref
- 30/10/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nanchang University pays non établi dans la noticeUniversité ou école supérieure
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Second Military Medical University pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Jiangxi Medical College pays non établi dans la noticeÉtablissement de santé
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Third Affiliated Hospital of Nanchang University pays non établi dans la noticeÉtablissement de santé
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Changhai Hospital pays non établi dans la noticeÉtablissement de santé
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Southern Medical University Dermatology Hospital pays non établi dans la noticeUniversité ou école supérieure
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Anhui University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Shenyang Pharmaceutical University pays non établi dans la noticeUniversité ou école supérieure
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Nanchang People's Hospital Affiliated of Nanchang Medical College Department of Clinical Laboratory pays non établi dans la noticeUniversité ou école supérieure
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the First Affiliated Hospital of Naval Medical University Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Anhui University of Chinese Medicine Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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College of life sciences and Biopharmaceuticals pays non établi dans la noticeUniversité ou école supérieure
Nanchang University, Second Military Medical University et First Affiliated Hospital of Jiangxi Medical College, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.