Impact of Reticular Pseudodrusen on Clinical and Ocular Characteristics and Progression Rate of Geographic Atrophy in Japanese Patients
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Le résumé fourni par la source
Purpose To elucidate the impact of reticular pseudodrusen (RPD) on the clinical and ocular characteristics and progression rate of geographic atrophy (GA) in Japanese patients. Design Multicenter, retrospective, observational cohort study. Participants A total of 173 eyes from 173 Japanese patients (135 with conventional GA and 35 with pachychoroid GA) were included; 79 eyes with conventional GA were included in the follow-up group. Methods Reticular pseudodrusen status, GA type (conventional/pachychoroid), GA location (central/non-central), GA pattern (unifocal/multifocal), subfoveal choroidal thickness (SFCT), and fellow-eye status were assessed using multimodal imaging. The GA progression rate was calculated in both mm 2 /year and mm/year (square root transformation; SQRT) after semi-automatic measurement of the GA area on fundus autofluorescence images. Main Outcome Measures Clinical and ocular characteristics and progression rate of GA according to RPD status. Results Reticular pseudodrusen were observed in 42.4% (73 eyes) of the 173 study eyes, 54.1% of the eyes with conventional GA, and none of the eyes with pachychoroid GA. Among patients with conventional GA, those with RPD were significantly more female (56.2 vs. 30.6%, P =0.003), had better visual acuity (0.31 vs. 0.50 in logarithm of the minimum angle of resolution, P =0.03), a smaller SFCT (141.7 vs. 185.0μm, P =0.02), higher prevalence of non-central (56.2 vs. 32.3%, P =0.005) and multifocal GA (68.5 vs. 29.0%, P <0.001), and bilateral late age-related macular degeneration (93.1 vs. 65.0%, P <0.0001) than those without RPD. The GA progression rate was significantly higher in eyes with RPD than in eyes without RPD (0.34 vs. 0.18 mm/year [SQRT], P <0.001). Conclusions Reticular pseudodrusen are frequently observed in Japanese patients with conventional GA. Clinical and ocular characteristics differ according to the RPD status, similarly in Caucasians. Geographic atrophy in the presence of RPD progresses rapidly, at a rate comparable to that in Caucasians, and most patients with RPD exhibit bilateral late AMD. Given that RPD in eyes with GA constitute a strong risk factor for both fast GA progression and bilateral late AMD, GA with RPD should be treated at an early stage prior to foveal involvement, even though GA in Asians has been reported to progress slowly.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of Reticular Pseudodrusen on Clinical and Ocular Characteristics and Progression Rate of Geographic Atrophy in Japanese Patients
- Date Crossref
- 01/02/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kyoto University Department of Ophthalmology and Visual Sciences pays non établi dans la noticeUniversité ou école supérieure
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Osaka Red Cross Hospital Department of Ophthalmology pays non établi dans la noticeÉtablissement de santé
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University of the Ryukyus pays non établi dans la noticeUniversité ou école supérieure
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Yokohama City University Department of Micro-Technology and Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Tokyo Women's Medical University Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Kansai Medical University Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Mie University Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Kagoshima University Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Medicine Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
Department of Ophthalmology and Visual Sciences — Kyoto University, Department of Ophthalmology — Osaka Red Cross Hospital et University of the Ryukyus, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.