The Precuneus Region Drives Brain Network Changes in Tremor‐Dominant Parkinson's Disease: Insights from a Morphological Causal Analysis
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The tremor-dominant (TD) subtype of Parkinson's disease (PD) is characterized by prominent tremor symptoms. However, the temporal and causal relationships between brain structural alterations in TD patients remain unexplored. A total of 61 TD patients and 61 matched healthy controls (HCs) were included in this study. The gray matter volume (GMV) of the bilateral precuneus (PCUN) was significantly reduced in TD patients. A structural covariance network analysis seeded with the left pallidum (PAL.L), which had the most significant differences, revealed a substantial reduction in covariance with precentral gyrus in TD patients. We performed a causal structural covariance network analysis using the TD duration as a pseudotime series. The PCUN, with the highest out-degree in the cortex, regulates numerous regions, including the supplementary motor area and the extensive temporal lobe. Machine learning was utilized to construct a model that accurately assesses the surgical prognosis based on the above cortical volume and clinical scale, with the aim of assisting in clinical deep brain stimulation (DBS) treatment. These findings suggested a progressive pattern of GMV changes extending from the PAL.L to the PCUN region and continuing to other brain regions, providing insights into the progression of TD and enhancing DBS treatment strategies.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Precuneus Region Drives Brain Network Changes in Tremor‐Dominant Parkinson's Disease: Insights from a Morphological Causal Analysis
- Date Crossref
- 26/10/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Capital Medical University Beijing Neurosurgical Institute pays non établi dans la noticeUniversité ou école supérieure
-
Shandong Tumor Hospital pays non établi dans la noticeÉtablissement de santé
-
Beijing Institute of Neurosurgery pays non établi dans la noticeStructure de recherche
-
Shandong First Medical University Department of Neurosurgery Shandong Cancer Hospital and Institute pays non établi dans la noticeUniversité ou école supérieure
-
Beijing Tian Tan Hospital pays non établi dans la noticeÉtablissement de santé
-
First Affiliated Hospital of Zhengzhou University Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
-
Shandong University of Aeronautics pays non établi dans la noticeUniversité ou école supérieure
-
Department of Humanities and Social Sciences Binzhou Medical University Shandong China Department of Humanities and Social Sciences pays non établi dans la noticeUniversité ou école supérieure
Beijing Neurosurgical Institute — Capital Medical University, Shandong Tumor Hospital et Beijing Institute of Neurosurgery, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.