S132 Evaluating the Severity of Acute Pancreatitis in Type 2 Diabetes Patients Treated With Incretin-Based Therapies vs Insulin: A Multicenter Retrospective Analysis Using APACHE II

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Introduction: Psychiatric illness, especially substance use disorders (SUD), is highly prevalent amongst patients hospitalized with acute pancreatitis (AP), yet its impact on procedural outcomes and delivery has not been well studied on a national scale. We aimed to assess how 6 psychiatric diagnostic categories influence access to guideline recommended interventions, hospital resource utilization, and timing of endoscopic retrograde cholangiopancreatography (ERCP) in AP. Methods: We analyzed adult AP admissions (ICD-10 K85) from the 2019 to 2021 NIS, grouping psychiatric comorbidities (ICD-10 F10-F69) into 6 categories. We excluded pregnancy, chronic pancreatitis, and pancreatic cancer. The primary outcome was receipt of any guideline directed intervention (ERCP ≤48 h, cholecystectomy ≤72 h, or drainage ≥14 d). Secondary outcomes were length of stay (LOS), charges, and time to ERCP in biliary AP cohort, adjusted for covariates. Results: Among 219,225 unweighted AP stays (weighted N ≈ 1,096,124), mean age was 53 years, mean LOS 5.6 days, and mean charges $72,700. Psychiatric diagnoses were present in 57% of acute pancreatitis admissions, with SUD alone in 45%. SUD was associated with 77% lower odds of receiving any guideline intervention (adjusted odds ratio [aOR] 0.23, 95% CI 0.21–0.24, P < 0.001), while mood (aOR 0.91, P = 0.024) and anxiety disorders (aOR 0.86, P = 0.002) showed smaller effects. Access was independently increased at large hospitals (aOR 1.36) and urban-teaching centers (aOR 1.80). Each additional comorbidity reduced odds (aOR 0.85 per condition). SUD reduced LOS by 13% and charges by 22% (both P < 0.001); mood disorders reduced LOS by 8.5% and charges by 12.9% (P < 0.001); anxiety slightly prolonged LOS (3.4%, P = 0.001). In the biliary AP subgroup (n = 24,553; 481 ERCPs), psychiatric status did not affect time-to-ERCP (P > 0.23), though urban-teaching hospitals nearly doubled ERCP speed (aHR 1.99, P = 0.008), and each additional comorbidity delayed ERCP by 15% (aHR 0.85, P < 0.001). Conclusion: In this cohort of patients admitted with AP, SUD was linked to significant disparities procedural care, however, subgroup analyses revealed that lower ERCP rates in SUD largely reflected clinical appropriateness, rather than under-utilization of procedures. In the subgroup analysis of the biliary AP cohort, psychiatric status did not delay ERCP delivery. Instead, medical complexity and rural hospital settings were the main barriers, emphasizing the need for targeted care strategies and equitable resource distribution to ensure timely, evidence-based management for complex AP patients.

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