S125 Comparison of Outcomes With Early vs Delayed Biliary Decompression After Endoscopic Ultrasound of Head of Pancreas Mass: A Population-Level Retrospective Analysis

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Introduction: Malignant biliary obstruction can occur with head of the pancreas (HOP) masses and is often managed by endoscopic retrograde cholangiopancreatography (ERCP) or interventional radiology (IR) biliary decompression. We aimed to determine the rate of ERCP or IR drainage following endoscopic ultrasound (EUS) for HOP mass, and to assess the impact of timing on need for subsequent procedures, 30-day readmission rates, and duration of chemotherapy. Methods: This retrospective study used the Market Scan Research Database from 2016 to 2022. Inclusion criteria comprised a diagnosis of malignant HOP mass (ICD-10: C25.0), an EUS CPT code and minimum 3-month follow-up. Patients were categorized into groups as per Figure 1 [Figures presented at ACG annual meeting]. Early biliary drainage was defined as patients that had a CPT code for ERCP or IR procedure within 3 days of index EUS. Delayed biliary drainage was defined by patients with a CPT code for ERCP or IR procedure >3 days after index EUS. Surgical interventions included ICD-10 codes for Whipple surgery variants. Never ERCP/IR group included patients that never had biliary intervention. Secondary outcomes included incidence of repeat ERCP, 30-day readmission rate following EUS, and duration of chemotherapy treatment. Statistical analysis included Wilcoxon rank sum test for continuous variables and chi-square tests for categorical measures. Results: A total of 4238 patients with HOP mass were identified; 39% had early ERCP drainage and 4% had early IR drainage. Of the group that underwent EUS alone, 26.9% (n = 649) subsequently underwent delayed biliary drainage. Baseline characteristics between delayed decompression and no ERCP/IR drainage were similar except for higher Charlson Comorbidity Index (P < 0.001) in the delayed drainage group. Within 30-days of ERCP drainage, most patients did not require re-intervention with a second ERCP (96.3% in early drainage group vs 95.9% in delayed biliary drainage group). The rate of repeat hospitalization for pancreatitis was higher in the early drainage group (4.4% vs 2.5%) while the rate of sepsis was higher in the delayed ERCP group (5.5% vs 4%). The duration of chemotherapy treatment did not vary by timing of ERCP. Conclusion: In patients with a HOP mass, malignant biliary obstruction resulted in early biliary drainage procedure in 43% of patients and delayed biliary drainage in 27% of patients. The readmission rate within 30-days of EUS were similar between the groups and there was no significant impact on chemotherapy duration.

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