Bleomycin-induced flagellate dermatitis in a South Indian patient with Hodgkin’s Lymphoma – A case report

Le résumé fourni par la source

Flagellate dermatitis is a rare skin reaction marked by linear or streak-like itchy red lesions, predominantly on the trunk and limbs. It is an uncommon cutaneous adverse effect of bleomycin, a chemotherapeutic drug used in treating cancers like Hodgkin’s lymphoma. The exact mechanism remains unclear. This case report details a 35-year-old male diagnosed with Hodgkin’s lymphoma who developed flagellate dermatitis after receiving doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy (adriamycin 25 mg, bleomycin 10 mg, vinblastine 6 mg, dacarbazine 520 mg). Six days post-treatment, he presented with intense itching and hyperpigmented, excoriated lesions on the neck, arms, chest, and back. A dermatologist confirmed the diagnosis of bleomycin-induced flagellate dermatitis. Treatment included the application of clindamycin gel, a combination of adapalene and clindamycin, an emollient lotion, an anti-acne cleansing bar, and oral levocetirizine 5 mg for 20 days. The patient showed gradual improvement. According to the World Health Organisation - Uppsala Monitoring Centre causality assessment, the skin reaction is possibly caused by bleomycin exposure.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.