Use of Dexmedetomidine as adjunct with Bupivacaine in TAP block for postoperative pain relief in patients undergoing laparoscopic cholecystectomy

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Objective: To analyze adjunct effect of Dexmedetomidine along with Bupivacain in TAP block for postoperative analgesia in laparoscopic cholecystectomy. Study Design and Setting: Prospective interventional study was conducted 1st September 2022 to 31st January 2023 at Anesthesia department of PAF Hospital Islamabad, affiliated with Air University. Methodology: A total of 60 patients undergoing elective laparoscopic cholecystectomy between age 18 to 60 years were included. Patients having hypertension, heart disease, diabetes were excluded. Group A patients were given TAP block using 10ml 0.25 % Bupivacaine on each side.Group B patients were given 10ml of 0.25% Bupivacaine with injection Dexmedetomidine 0.5 µg/kg in divided dose on each side under ultrasound guidance. Patients were followed for postoperative pain in first 24 hours. Results: Data was analyzed on SPSS 25.Mean ± SD of pain score on VAS was 6.54 ± 1.98 versus 3.54 ± 1.87 at 4 hours ( p value =0.0001) , 5.51 ± 1.16 versus 2.89 ± 1.65 at 8 hours ( p value=0.0001) , 4.89 ± 1.11 versus 2.13 ± 1.25 at 12 hours ( p value=0.0001) ,4.47 ± 1.07 versus 1.63 ± 0.85 at 24 hours ( p value=0.0001) in group A and B respectively. Stratification was done with age, gender, ASA status and duration of surgery .Results of study were not affected by these factors. Conclusion: Dexmedetomidine when added as an adjunct to Bupivacaine is better than Bupivacaine alone in TAP block for postoperative analgesia after laparoscopic cholecystectomy

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