Zoonotic Escherichia coli and urinary tract infections in Southern California
Rattachement africain : us, gb, dk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
ABSTRACT Extraintestinal pathogenic Escherichia coli (ExPEC) is the leading cause of urinary tract infections (UTIs) worldwide and may be transmitted from food animals to humans via contaminated meat. However, the contribution of zoonotic ExPEC strains to UTIs in metropolitan areas remains unclear. We estimated the proportion of UTIs attributable to zoonotic ExPEC across eight Southern California counties. Between 2017 and 2021, we collected 12,616 E. coli isolates from retail meat and 23,483 from UTI patients, sequencing a representative subset of 5,728 isolates. Using a Bayesian latent class model trained with 17 host-associated genetic markers, we inferred the host origin of each isolate. Demographic, clinical, and antimicrobial resistance profiles were compared between meat isolates and clinical isolates inferred to be of human or food-animal origin. Most UTI patients were female (88%), with a median age of 50 years; 37% were Hispanic and 31% non-Hispanic white. Zoonotic ExPEC strains accounted for 18% of UTIs overall, rising to 21.5% in high-poverty neighborhoods. Women had a higher zoonotic proportion than men (19.7% vs 8.5%, P < 0.001). Among men, those with zoonotic infections were older than those with non-zoonotic infections (median 73.0 vs 65.0 years, P = 0.028). These findings underscore the contribution of zoonotic ExPEC to the UTI burden in Southern California and the need for targeted interventions to reduce risk in vulnerable communities. IMPORTANCE Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and are primarily caused by Escherichia coli . While E. coli is known to colonize both humans and food-producing animals, the extent to which zoonotic strains impact human disease remains poorly understood. Emerging evidence suggests that food animals may serve as an underrecognized reservoir for extraintestinal pathogenic E. coli (ExPEC). In this study, we used a genomic attribution model to quantify the contribution of zoonotic strains to UTIs in Southern California. We found that approximately 18% of E. coli UTIs were likely attributable to food animals. Individuals living in high-poverty neighborhoods had a 1.6-fold increased risk of zoonotic UTIs compared to those in low-poverty areas. These findings highlight zoonotic transmission as an important driver of UTIs and suggest that reducing ExPEC in food-animal reservoirs could help lower disease burden and address health disparities.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Zoonotic <i>Escherichia coli</i> and urinary tract infections in Southern California
- Date Crossref
- 12/11/2025
- Éditeur
- American Society for Microbiology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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George Washington University Department of Environmental and Occupational Health pays non établi dans la noticeUniversité ou école supérieure
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University of Cambridge Department of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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Bloomberg (United States) pays non établi dans la noticeEntreprise
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Johns Hopkins University Center for a Livable Future pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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Kaiser Permanente Department of Health Systems Science pays non établi dans la noticeOrganisation à but non lucratif
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Kaiser Permanente Bernard J. Tyson School of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Statens Serum Institut Department of Sequencing and Bioinformatics pays non établi dans la noticeStructure de recherche
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University of Oxford Centre for Genomic Pathogen Surveillance Big Data Institute pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins School of Public Health Department of Environmental Health and Engineering pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins School of Medicine Department of Molecular and Comparative Pathobiology and Division of Infectious Diseases pays non établi dans la noticeUniversité ou école supérieure
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Department of Research & Evaluation pays non établi dans la noticeInstitution
Department of Environmental and Occupational Health — George Washington University, Department of Veterinary Medicine — University of Cambridge et Bloomberg (United States), avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.