Neural Network Dysregulation in Female Abdominal Obesity: Distinct Functional Connectivity in Different Appetite Subtypes
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OBJECTIVE: This study investigated the neural mechanisms underlying appetite dysregulation in female subjects with abdominal obesity (AO) by identifying functional connectivity (FC) and network-level differences between moderate appetite (MA) and strong appetite (SA) subtypes. METHODS: A total of 60 women with AO (30 MA, 30 SA) and 30 healthy controls (HCs) underwent resting-state fMRI. Independent component analysis was used to identify and examine FC within and functional network connectivity (FNC) between key resting-state networks, including those involved in cognitive and visual processing. Network alterations and correlations with obesity-related indicators were evaluated. RESULTS: Compared to HCs, both groups showed reduced FC in the default mode network (DMN) and visual network (VN), with SA additionally exhibiting decreased FC in the frontoparietal network (FPN) and lower angular gyrus FC than MA (p < 0.05, FDR-corrected). MA displayed increased DMN-left FPN (FPN_L) FNC (p < 0.001), while SA showed negative correlations between FC and BMI/appetite visual analog scale (VAS) scores in FPN and with body weight/BMI/appetite VAS in VN (p < 0.05). In HCs, DMN-FPN_L FNC positively correlated with BMI, a pattern that was not observed in MA. CONCLUSION: Distinct brain network patterns characterize appetite subtypes in AO. SA showed more pronounced FC reductions in networks previously linked to self-regulation and visual processing, which may contribute to appetite dysregulation based on correlations with obesity indicators. In contrast, MA exhibited increased DMN-FPN_L FNC, potentially reflecting adaptive internetwork interactions.
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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neural Network Dysregulation in Female Abdominal Obesity: Distinct Functional Connectivity in Different Appetite Subtypes
- Date Crossref
- 23/10/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Yunnan University Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment pays non établi dans la noticeUniversité ou école supérieure
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Kunming Medical University Department of Medical Imaging pays non établi dans la noticeUniversité ou école supérieure
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Second People's Hospital of Yunnan Province pays non établi dans la noticeÉtablissement de santé
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Yunnan University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Chengdu University of Traditional Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Kunming Medical University pays non établi dans la noticeÉtablissement de santé
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School of Second Clinical Medicine/The Second Affiliated Hospital pays non établi dans la noticeUniversité ou école supérieure
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College of Acupuncture and Tuina pays non établi dans la noticeUniversité ou école supérieure
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The Sports Trauma Specialist Hospital of Yunnan Province Kunming China pays non établi dans la noticeÉtablissement de santé
Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment — Yunnan University, Department of Medical Imaging — Kunming Medical University et Second People's Hospital of Yunnan Province, avec 6 autres affiliations.
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