Macular Thickness and Its Associated Factors in a Healthy Cynomolgus Colony: The Non-Human Primates Eye Study

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Purpose: The research aims to investigate the normal macular thickness range in a healthy cynomolgus colony and examine its association with relevant parameters. Design: Cross-sectional observational study. Subjects: A total of 418 healthy cynomolgus monkeys (mean age, 13.22 ± 7.86 years; range, 1-29 years) from the Non-Human Primates Eye Study conducted between 2021 and 2022. Methods: ), was used to examine the relationships between macular subregions and age. Additionally, univariate analyses and multivariate linear regression were conducted to evaluate the associations between the central, average inner ring, and average outer macular thickness and various systemic and ophthalmic parameters. Main Outcome Measures: Macular thickness in ETDRS subfields and its associations with age and ocular parameters. Results: Sex statistically significant differences were observed only in the superior sector of the inner ring and in the temporal sector of the outer ring after adjustment. In inner rings, all 4 subfields exhibited a significant age-related decline; meanwhile, temporal and superior subfields decreased with increasing age in the outer ring. After adjustment, macular thickness was independently associated with age and end-of-anesthesia intraocular pressure (IOP) in the central region, axial length (AXL) in the average inner ring, AXL and mid-anesthesia IOP in the average outer ring, and AXL and end-of-anesthesia IOP for the overall average thickness. Conclusions: This study provided valuable reference data on macular thickness in different ages and sexes of cynomolgus which could be utilized in preclinical nonhuman primate experiments. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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