Complex Reassortment Dynamics of H9N2 Avian Influenza Viruses in Xinjiang, China: Implications for Zoonotic Spillover
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: H9N2 avian influenza viruses (AIVs) donate their genes to other subtype AIVs, posing significant threats to poultry industries and public health due to their endemicity and zoonotic potential. This study investigates the molecular evolution, reassortment, and mutations of the H9N2 isolates from the live poultry markets (LPMs) in Xinjiang, China. METHODS: AIVs were isolated from oropharyngeal and cloacal swabs, as well as environmental samples collected during the winter of 2017-2018. Full-genome sequencing and phylogenetic and molecular analysis were conducted to elucidate viral origins, reassortment patterns, and molecular characteristics. RESULTS: Thirty H9N2 isolates were obtained, all belonging to the G57 genotype. Phylogenetic analysis revealed three distinct Eurasian lineages: BJ/94-like (HA, NA), G1-like (PB2, MP), and F98-like. Notably, viral genes diverged into two major branches (A/B), with the A branches of HA, PB2, PA, and NS further subdivided into A1/A2 sublineages. In addition to the A and B branches, the viral genes of several isolates formed independent phylogenetic branches. Some of the viral genes clustered together with H9N2 viruses from the poultry/environmental strains in China and Japan, and some viral genes (e.g., PB2, PB1, MP, and NS) showed close phylogenetic relationships with human-infecting H9N2/H7N9 viruses. The multiple mutations detected in the isolates were associated with viral virulence, mammalian adaptation, and transmission. CONCLUSION: Xinjiang H9N2 viruses display complex reassortment dynamics involving multiple geographic lineages. Their genetic connection to human-infecting strains underscores the risk of zoonotic spillover. Enhanced surveillance in LPMs is crucial for pandemic preparedness.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Complex Reassortment Dynamics of H9N2 Avian Influenza Viruses in Xinjiang, China: Implications for Zoonotic Spillover
- Date Crossref
- 01/10/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
China Academy of Chinese Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Xinjiang University Xinjiang Key Laboratory of Biological Resources and Genetic Engineering pays non établi dans la noticeUniversité ou école supérieure
-
Xinjiang Production and Construction Corps pays non établi dans la noticeOrganisation à but non lucratif
-
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center pays non établi dans la noticeOrganisme public
-
Chinese Academy of Sciences pays non établi dans la noticeOrganisme public
-
Institute of Microbiology pays non établi dans la noticeStructure de recherche
-
Karamay Central Hospital of Xinjiang pays non établi dans la noticeÉtablissement de santé
-
Xinjiang Second Medical College pays non établi dans la noticeUniversité ou école supérieure
-
CAS Key Laboratory of Pathogenic Microbiology and Immunology pays non établi dans la noticeStructure de recherche
China Academy of Chinese Medical Sciences, Xinjiang Key Laboratory of Biological Resources and Genetic Engineering — Xinjiang University et Xinjiang Production and Construction Corps, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.