Effects of Circadian Misalignment on Young and Aging Salivary Glands
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Le résumé fourni par la source
Several empirical observations strongly suggest that salivary function is regulated by the circadian clock. Salivary volume, electrolytes levels, and saliva protein composition all show 24-h cycle fluctuations. The exact effects of circadian disruption on salivary gland (SG) physiology and its potential role in salivary pathologies have not been elucidated. Here, we examined the effects of circadian disruption on SG structure, functional gene and protein expression, and immune status using several circadian knockout (KO) mice models where we targeted the following canonical clock genes: brain and muscle ARNT-like 1 protein ( Bmal1 ) KO, Period2 ( Per2 ) KO, Cryptochrome1 ( Cry1 ) KO, Cryptochrome2 ( Cry2 ) KO, and Cryptochrome 1 and 2 double KO ( DKOCry ). All mice were females of young and old age, and data were compared with wild type (control) mice. Our results showed that circadian dysregulation had limited effects on stimulated salivary secretion and SG structure. Yet, circadian disruption significantly affected the expression of several key salivary markers, including mucins, amylase, and aquaporins, in young and aged SGs with increased amylase and acidic mucin production observed in several KO models. In addition, targeting of clock genes has resulted in subtle alterations of the salivary immune microenvironment with increased lymphocyte infiltration and upregulated levels of proinflammatory cytokines. These immune shifts were more pronounced in aged glands with the most proinflammatory phenotypes observed in DKOCry and Bmal1KO mice. Collectively, our results implicate the circadian clock in the intricate temporal regulation governing SG function. Our data also suggest that circadian dysregulation may predispose to increased tissue stress and inflammation. Exploration of salivary system chronobiology represents a new avenue for salivary disease prevention and treatment.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effects of Circadian Misalignment on Young and Aging Salivary Glands
- Date Crossref
- 18/10/2025
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Saskatchewan pays non établi dans la noticeUniversité ou école supérieure
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Centre hospitalier universitaire de Québec pays non établi dans la noticeÉtablissement de santé
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Arthritis Research Centre of Canada pays non établi dans la noticeOrganisation à but non lucratif
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Université Laval ARThrite Research Center (Arthrite Research Treatment) pays non établi dans la noticeUniversité ou école supérieure
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Canadian Rural Health Research Society pays non établi dans la noticeInstitution
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University of Foggia Department of Clinical and Experimental Medicine pays non établi dans la noticeUniversité ou école supérieure
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College of Medicine Department of Anatomy pays non établi dans la noticeUniversité ou école supérieure
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Faculté de Médecine Dentaire Interdisciplinary Center for Clinical and Applied Research and Entrepreneurship/Centre interdisciplinaire pour la recherche clinique et appliqué pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Ophthalmology and ENT–Head and Neck Surgery pays non établi dans la noticeUniversité ou école supérieure
University of Saskatchewan, Centre hospitalier universitaire de Québec et Arthritis Research Centre of Canada, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.