Overcoming natural replication barriers formed by DNA structures and the role of repositioning to the nuclear periphery

Le résumé fourni par la source

Endogenous barriers to DNA replication, such as repetitive DNA, non-B DNA structures, and protein barriers present significant challenges to replication. Upon encountering one of these barriers, cells employ a number of strategies to ensure completion of replication. Some of these pathways operate at the stalled replication fork and others occur post-replicatively. These pathways vary both in their timing and the nuclear location in which they occur. Here we review how cells deal with endogenous sources of replication stress, with a focus on structure-forming DNA repeats, and our current understanding of how cells use nuclear positioning to facilitate the repair of natural replication barriers.

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