Split Face Comparative Study of Microneedling with Platelet-rich Plasma versus Microneedling Alone in Treating Atrophic Postacne Scars

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Context: Acne vulgaris can be defined as a chronic inflammatory disease that involves pilosebaceous unit, due to increased sebum production, disordered keratinization, microbial colonization of hair follicles, and inflammation. Inflammatory acne lesions are usually responsible for the scar formation. Aims: To compare the efficacy of microneedling with platelet-rich plasma (PRP) against microneedling alone in treating atrophic postacne scars in a split face design. Materials and Methods: Patients with atrophic postacne scars, who attended the dermatology outpatient department, were offered four sittings of treatment at an interval of 4 weeks between sessions. As a standard protocol, right side of the face subjected to microneedling with PRP and left side of the face treated with microneedling. Acne scars were graded according to Goodman and Baron quantitative and qualitative global acne scar grading system. Visual analog score (VAS) was calculated based on both patient and physician assessment. Results: In our study, majority (50%) belonged to age group of 25–30 years. 70% of patients were male. Excellent response was more (37%) on the combination group and good response in the microneedling group (41%). Grades before and after treatment on both side of face and between both sides were statistically significant ( P < 0.05). Quantitative score showed 55.29% and 33.89% reduction in score on right and left side, respectively ( P < 0.05). VAS showed statistical significant difference between right and left side ( P < 0.05). Conclusions: Microneedling when combined with PRP seems to be a promising treatment of atrophic acne scars both qualitatively and quantitatively compared to microneedling alone.

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