Noninvasive Assessment Methods for the Therapeutic Effect Following Facial Rejuvenation

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BACKGROUND: As the demand for facial rejuvenation continues to rise, monitoring the response to therapy is worthy of attention. However, a standardized system for assessing therapeutic effects is currently lacking. This study aims to review the existing noninvasive efficacy evaluation tools for facial rejuvenation and analyze their advantages and disadvantages. METHODS: An extensive literature search was conducted in PubMed to identify articles on efficacy evaluation tools for facial rejuvenation published between 1995 and 2024. RESULTS: We classify the available measurement tools as subjective assessment methods, imaging techniques, and biophysical methods. Most subjective scales are based on clear definitions and standardized photographs, which are evaluated by dermatologists. Various scales focusing on different clinical features are continuously being developed, making it challenging to compare study outcomes. Imaging techniques are generally more precise and accurate. The information collected by these techniques is more convenient to store, search, and analyze, indicating their significant potential for monitoring efficacy. However, the high cost of equipment and complexity of operation may limit the application. Biophysical parameters can indirectly measure the severity of skin aging, but their repeatability and accuracy require further validation. CONCLUSION: This review offers a comprehensive overview of the existing efficacy evaluation methods for facial rejuvenation and discusses pertinent details. There is no single best assessment method. When selecting outcome measures in clinical practice or scientific research, several factors must be considered, including therapeutic objectives, convenience, and accuracy.

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