Design, Synthesis, In‐Vitro, In‐Vivo, and In‐Silico Evaluations of New Fibric Acid Derived 1,3,4‐Oxadiazole‐Based N ‐Substituted Acetamides as Anti‐Inflammatory Agents
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Le résumé fourni par la source
Abstract Medical research in Chemistry has concentrated on developing and examining oxadiazole derivatives of fibric acid for many years. Heterocyclic compounds require oxadiazole derivatives for their development process. Laboratory synthesis yielded a new set of fibric acid hybrid compounds with fibric acid residue together with 1,3,4‐oxadiazole ring and N ‐substituted acetamides core which was verified using TLC, FTIR, H 1 ‐NMR and C 13 ‐NMR. A combined structure within the compounds increased their potency to inhibit cyclooxygenase (COX‐2) through this combination effect. Researchers conducted in vivo and in vitro experiments using the carrageenan‐induced hind paw‐edema model and percentage inhibition of protein denaturation method respectively to assess anti‐inflammatory potential. The effects of compounds were evaluated against standard diclofenac sodium (100 µL/mL). PDB ID (3LN1) was used to study the binding compatibility of target chemicals with cyclooxygenase (COX‐2) proteins through in silico molecular docking tests. In vitro compounds 7f and 7a show highest anti‐inflammatory activity among all synthesized compounds, near to standard drug diclofenac sodium, while the compound 4 depicted least activity among others. In vivo compounds 7f , 7a , 7c, and 7g show higher activity even than standard drug. The compound 4 has shown least anti‐inflammatory potential. From docking study, it has been inferred that all synthesized ligands except 4 have excellent docking score even greater than standard diclofenac sodium. Compound 7f have highest energy score 6174 with an ACE value −378.06 kcal/mol. The similar findings from dry and wet lab experiments demonstrated compound 7f has potential to act as a base structure for developing powerful anti‐inflammatory agents.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Design, Synthesis, In‐Vitro, In‐Vivo, and In‐Silico Evaluations of New Fibric Acid Derived 1,3,4‐Oxadiazole‐Based <i>N</i> ‐Substituted Acetamides as Anti‐Inflammatory Agents
- Date Crossref
- 01/10/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of the Punjab pays non établi dans la noticeUniversité ou école supérieure
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Government College University pays non établi dans la noticeUniversité ou école supérieure
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Government Graduate College Township Lahore pays non établi dans la noticeUniversité ou école supérieure
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Government College of Science pays non établi dans la noticeUniversité ou école supérieure
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University of Lahore pays non établi dans la noticeUniversité ou école supérieure
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Pakistan Council of Scientific & Industrial Research pays non établi dans la noticeOrganisme public
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Applied Chemistry Research Centre PCSIR Laboratories Complex Ferozpur Road Lahore 54600 Pakistan pays non établi dans la noticeStructure de recherche
University of the Punjab, Government College University et Government Graduate College Township Lahore, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.