Nutritional Adequacy and Day-to-Day Energy Variability: Impacts on Outcomes in Severe Trauma Patients
Rattachement africain : rs, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Optimal energy and protein delivery during the early phase of severe trauma remains unclear. Observational studies frequently contradict the findings of randomized controlled trials, raising concerns about confounding factors. The aim of this study is to assess nutritional adequacy and daily variability in the energy gaps and its impact on outcomes using innovative statistical methods. Methods: Prospective observational study enrolled severely injured patients in the ICU at the Level 1 trauma center between October 2023 to April 2025. To describe the evolution of calorie and protein deficits during the first 10-day ICU stay, we utilized a linear mixed-effects model to estimate each patient’s individual energy gap trajectory. Results: 286 patients were analyzed. Median APACHE II and ISS score was 16.0 (12.0–20.0) and 22.0 (18.0–27.0), respectively. Mortality rate was 35.3%. Patients received 68.3% of prescribed calories and 76.8% of proteins. Admission energy deficit, rate of caloric intake, and their interaction are associated with ICU mortality. Increased day-to-day energy variability was associated with longer duration of mechanical ventilation (HR = 0.55, 95% CI: 0.31–0.99; p = 0.047). Patients who achieved better caloric (HR = 0.68, 95% CI: 0.48–0.98, p = 0.036) and protein (HR = 0.29, 95% CI: 0.09–0.96, p = 0.043) nutrition had a lower hazard of developing nosocomial infection. Conclusions: This study supports the 2023 ESPEN guidelines, showing that achieving the recommended energy and protein intake during the early phase of severe trauma is linked to lower mortality rates, shorter mechanical ventilation time, and reduced risk of nosocomial infections.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Nutritional Adequacy and Day-to-Day Energy Variability: Impacts on Outcomes in Severe Trauma Patients
- Date Crossref
- 09/10/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Belgrade pays non établi dans la noticeUniversité ou école supérieure
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Centar za Promociju Nauke pays non établi dans la noticeOrganisme public
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Center for Digestive and Liver Diseases pays non établi dans la noticeStructure de recherche
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Military Medical Academy pays non établi dans la noticeÉtablissement de santé
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University Clinical Center of Serbia Department of Anesthesiology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Institute for Medical Statistics and Informatics pays non établi dans la noticeUniversité ou école supérieure
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University of Defense Department of Hepatobiliary and Pancreatic Surgery pays non établi dans la noticeUniversité ou école supérieure
University of Belgrade, Centar za Promociju Nauke et Center for Digestive and Liver Diseases, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.