Left ventricular geometry, brain architecture, and cognition: an observational study
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Le résumé fourni par la source
BACKGROUND AND AIMS: Cardiovascular (CV) diseases and dementia share common risk factors and often coexist in older adults. Understanding the CV-brain interaction is essential for tackling their interconnected burden. This study investigated the link between CV phenotypes, brain architecture, and cognition. METHODS: Overall, 15 519 UK Biobank participants without neurodegenerative diseases or stroke (median age 64 years, 49% female) were analysed. Confirmatory factor analysis aggregated 18 CV magnetic resonance imaging (MRI) biomarkers into latent variables for left ventricular systolic function (gSyst), diastolic (gDiast) function, and geometry (gGeom); arterial compliance was measured by aortic distensibility (AoD). Multivariable linear regression models evaluated associations with brain MRI phenotypes, including grey matter volume, white matter hyperintensities, MRI diffusion white matter microstructure, and hippocampal volume. Models were adjusted for age, body mass index, height, mean blood pressure, and CV risk factors. Exploratory mediation models evaluated whether hippocampal volume accounted for associations between CV phenotypes and cognition. RESULTS: gGeom, reflecting greater myocardial mass, wall thickness, and ventricular volumes, showed the strongest association with hippocampal volume [β = 0.082 (0.048-0.117) in females; β = 0.039 (0.006-0.071) in males] and was the only CV phenotype associated with better cognition, including higher fluid intelligence and faster reaction time. Hippocampal volume significantly accounted for the positive relationship between gGeom and cognition across sexes. In contrast, gSyst, gDiast, and AoD demonstrated weaker and less consistent associations with brain structure and were unrelated to cognition. CONCLUSIONS: Ventricular geometry emerged as the CV phenotype most strongly associated with brain architecture and cognition. Hippocampal volume may help explain this association, but further studies are needed to investigate causality.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Left ventricular geometry, brain architecture, and cognition: an observational study
- Date Crossref
- 09/10/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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St Thomas' Hospital pays non établi dans la noticeÉtablissement de santé
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British Heart Foundation pays non établi dans la noticeOrganisation à but non lucratif
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King's College London pays non établi dans la noticeUniversité ou école supérieure
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Scuola Superiore Sant'Anna pays non établi dans la noticeUniversité ou école supérieure
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King's College School pays non établi dans la noticeUniversité ou école supérieure
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School of Biomedical Engineering and Imaging Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Life Course and Population Sciences Department of Twin Research and Genetic Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Institute of Management pays non établi dans la noticeStructure de recherche
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GKT School of Medical Education pays non établi dans la noticeUniversité ou école supérieure
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School of Cardiovascular Medicine & Metabolic Medicine & Sciences pays non établi dans la noticeUniversité ou école supérieure
St Thomas' Hospital, British Heart Foundation et King's College London, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.